Reaction Biologyでは、各種Biochemical Assay, Cell-base Assay, Biophysica Assay, in vivo Assay等、下記様々なアッセイ系を提供しています。
- Biochemical Assays
キナーゼ
キナーゼパネルアッセイ
エピジェネティック関連 (HMT、Demethylase、HAT、HDAC、IDH、BRD等)
Safetyパネル
その他 (プロテアーゼ、約20種類のホスファターゼ、PDE、DUB、PARP等) - Full Panel Screening 毎月定期的に実施するパネル試験
Wildtype, Mutant, Atypical, Lipid kinase, and DGK Panels (1uM, 10uM)
Wildtype, Mutant, Atypical, Lipid kinase, and DGK Panels (1mM ATP)
Diversify Kinase Panel (1mM ATP)
Methyltransferase Full Panel
Histone Deacetylase (HDAC) Full Panel
Protease Full Panel
Phosphodiesterase (PDE) Full Panel - Cell-base Assays
NanoBRET™ Target Engagement Intracellular Kinase Assays
細胞増殖アッセイ、細胞増殖パネルアッセイ - Biophysical Assays
Surface Plasmon Resonance (SPR)
Isothermal Titration Calorimetry (ITC)
Microscale Thermophoresis (MST)
Thermal Shift Assay (TSA) - In vivo Assays
Cell-line-derived Xenograft (CDX) モデルアッセイ
Antibody-Drug Conjugate (ADC)創薬プログラムも、下記アッセイステップにてサポートします。
- Antigen binding specificity and potency
ポスター："Development and evaluation of a high-throughput method for rapid detection of surface antigen expression in fixed cells"
- Internalization kinetics
- Payload cytotoxicity profiling
ポスター："In Vitro Comparison of Kadcyla® and Enhertu® in Breast Cancer with Varying HER2 Expression: Proliferation, Internalization, and Bystander Effects" - In vivo assessment of pharmacokinetics, biodistribution, and efficacy
- Antigen binding specificity and potency