Biochemical Assay - KinSight™ Kinase Profiling

AssayQuantのKinSight™ Kinase Profilingでは、独自のPhosphoSens^® Technologyを用いることにより、反応全体を通じて基質のリン酸化/脱リン酸化をリアルタイムで直接測定することが可能です。PhosphoSens^®の中核をなすは、Chelation-enhancedのSox（スルホンアミドオキシン）蛍光色素です。Nativeなペプチド配列に基づいて設計されたPhosphoSens^®基質により、基質レベルのリン酸化活性を、リアルタイムかつ定量的に測定します。Timie-dependent-inhibition (TDI)の特性評価も可能で、End-pointの阻害率評価だけでは分からない、化合物の選択性、最適化、オフターゲットの早期発見等に有用です。[ATP]はKmもしくは1 mMの選択が可能です。

Deliverables;
Detailed Kinetic Report for each compound that includes % inhibition presented in:
Numerical Format (Tabular), % inhibition for each enzyme
Graphical Format (Waterfall Plot), % inhibition for each enzyme
Graphical Format (Waterfall Plot), >70% inhibition
Visual Format (Kinome Tree), >70% inhibition
Also includes annotated progress curves for any exploitable mechanisms of actions (TDI).

KinSight™ Kinase Profiling

	Target name	Ser(S)/Thr(T) or Tyr(Y)	Full panel	WT panel	Tyrosine panel	CDK panel	Mutant panel	Kinode panel
1	AAK1	S/T	✓	✓
2	ABL1	Y	✓	✓	✓			✓
3	ABL1 [E255K]	Y	✓				✓
4	ABL1 [E255V]	Y	✓				✓
5	ABL1 [H396P]	Y	✓				✓
6	ABL1 [Q252H]	Y	✓				✓
7	ABL1 [T315I]	Y	✓				✓
8	ABL1 [Y253F]	Y	✓				✓
9	ABL1 [Y253H]	Y	✓				✓
10	ABL2 (ARG)	Y	✓	✓	✓
11	AKT1 (PKB)	S/T	✓	✓				✓
12	AKT2 (PKBb)	S/T	✓	✓
13	AKT3 (PKBg)	S/T	✓	✓
14	ALK	Y	✓	✓	✓
15	ALK [C1156Y]	Y	✓				✓
16	ALK [F1174L]	Y	✓				✓
17	ALK [G1202R]	Y	✓				✓
18	ALK [G1269A]	Y	✓				✓
19	ALK [L1196M/G1202R]	Y	✓				✓
20	ALK [L1196M]	Y	✓				✓
21	ALK [R1275Q]	Y	✓				✓
22	ALK [T1151‐L1152 INS T]	Y	✓				✓
23	ALK:NPM1 (NPM1‐ALK)	Y	✓				✓
24	AURKA (AURA)	S/T	✓	✓				✓
25	AURKB (AURB)	S/T	✓	✓				✓
26	AURKB (AURB) [G160L]	S/T	✓				✓
27	AURKC (AURC)	S/T	✓	✓
28	AXL	Y	✓	✓	✓
29	BCKDK	S/T	✓	✓
30	BCR RET (fusion)	Y	✓				✓
31	BLK	Y	✓	✓	✓
32	BMP2K (BIKE)	S/T	✓	✓
33	BMX	Y	✓	✓	✓
34	BRAF (BRAF1, RAFB1)	S/T	✓	✓				✓
35	BRAF, b-[V600E]	S/T	✓				✓
36	BRAF, b-[V600E]	S/T	✓				✓
37	BRSK1	S/T	✓	✓
38	BRSK2	S/T	✓	✓
39	BTK	Y	✓	✓	✓			✓
40	BTK [C481S]	Y	✓				✓
41	BUB1	S/T	✓	✓
42	BUB1B (BUBR1)	S/T	✓	✓
43	CAMK1 (CAMK1α)	S/T	✓	✓				✓
44	CAMK1D (CAMK1δ)	S/T	✓	✓
45	CAMK1G (CAMK1γ)	S/T	✓	✓
46	CAMK2A (CAMK2α)	S/T	✓	✓
47	CAMK2B (CAMK2β)	S/T	✓	✓
48	CAMK2D (CAMK2δ)	S/T	✓	✓
49	CAMK2G (CAMK2γ)	S/T	✓	✓
50	CAMK4	S/T	✓	✓
51	CAMKK1	S/T	✓	✓
52	CAMKK2	S/T	✓	✓
53	CDC42BPA (MRCKA)	S/T	✓	✓
54	CDC42BPB (MRCKB)	S/T	✓	✓
55	CDC42BPG (DMPK2)	S/T	✓	✓
56	CDC7/DBF4 (CDC7)	S/T	✓	✓
57	CDK1 (CDC2)/CycA1	S/T	✓	✓		✓
58	CDK1 (CDC2)/CycA2	S/T	✓	✓		✓
59	CDK1 (CDC2)/CycB1	S/T	✓	✓		✓		✓
60	CDK1 (CDC2)/CycE1	S/T	✓	✓		✓
61	CDK2/CycA1	S/T	✓	✓		✓
62	CDK2/CycA2	S/T	✓	✓		✓
63	CDK2/CycE1	S/T	✓	✓		✓
64	CDK2/CycE2	S/T	✓	✓		✓
65	CDK2/CycO	S/T	✓	✓
66	CDK3/CycE1	S/T	✓	✓		✓
67	CDK3/CycE2	S/T	✓	✓		✓
68	CDK4/CycD1	S/T	✓	✓		✓		✓
69	CDK4/CycD2	S/T	✓	✓		✓
70	CDK4/CycD3	S/T	✓	✓		✓
71	CDK5/p25	S/T	✓	✓		✓
72	CDK5/p35NCK	S/T	✓	✓		✓
73	CDK6/CycD1	S/T	✓	✓		✓
74	CDK6/CycD2	S/T	✓	✓		✓
75	CDK6/CycD3	S/T	✓	✓		✓
76	CDK7/CycH/MAT1	S/T	✓	✓		✓		✓
77	CDK7/CycH1	S/T	✓	✓		✓
78	CDK9 (TAK)/CycK	S/T	✓	✓		✓
79	CDK9 (TAK)/CycT1	S/T	✓	✓		✓
80	CDK9 (TAK)/CycT2	S/T	✓	✓		✓		✓
81	CDK12 (CRK7)/CycK	S/T	✓	✓		✓
82	CDK13 (CHED)/CycK	S/T	✓	✓		✓
83	CDK14 (PFTAIRE1, PFTK1)/CycY	S/T	✓	✓		✓
84	CDK15 (PFTAIRE2, PFTK2)/CycB1	S/T	✓	✓		✓
85	CDK16 (PCTAIRE1, PCTK1)/CycY	S/T	✓	✓		✓
86	CDK17 (PCTAIRE2, PCTK2)/CycY	S/T	✓	✓		✓
87	CDK17 (PCTAIRE2, PCTK2)/p35NCK	S/T	✓	✓		✓
88	CDK18 (PCTAIRE3, PCTK3)/CycY	S/T	✓	✓		✓
89	CDK19 (CDK11)/CycC	S/T	✓	✓		✓
90	CDKL5	S/T	✓	✓
91	CHEK1 (CHK1)	S/T	✓	✓				✓
92	CHEK2 (CHK2)	S/T	✓	✓
93	CHUK (IKKA, IKKa)	S/T	✓	✓
94	CIT (CRIK)	S/T	✓	✓
95	CLK1	S/T	✓	✓
96	CLK2	S/T	✓	✓				✓
97	CLK3	S/T	✓	✓
98	CLK4	S/T	✓	✓
99	CSF1R (FMS)	Y	✓	✓	✓
100	CSK	Y	✓	✓	✓
101	CSNK1A1 (CK1A1, CK1α)	S/T	✓	✓				✓
102	CSNK1A1L (CK1A1L, CK1a2)	S/T	✓	✓
103	CSNK1D (CK1D, CK1δ)	S/T	✓	✓
104	CSNK1E (CK1E, CK1ε)	S/T	✓	✓
105	CSNK1G1 (CK1G1, CK1γ1)	S/T	✓	✓				✓
106	CSNK1G2 (CK1G2, CK1γ2)	S/T	✓	✓
107	CSNK1G3 (CK1G3, CK1γ3)	S/T	✓	✓
108	CSNK2A1 (CK2A1, CK2α1)	S/T	✓	✓				✓
109	CSNK2A2 (CK2A2, CK2α2)	S/T	✓	✓
110	DAPK1	S/T	✓	✓
111	DAPK2 (DRP-1)	S/T	✓	✓				✓
112	DAPK3 (ZIPK)	S/T	✓	✓
113	DCLK1 (DCAMKL1)	S/T	✓	✓				✓
114	DCLK2 (DCAMKL2)	S/T	✓	✓
115	DDR1 [SRC treated]	Y	✓	✓	✓
116	DDR2	Y	✓	✓	✓
117	DMPK (DMPK1)	S/T	✓	✓
118	DSTYK (RIPK5, SGK496)	S/T	✓	✓
119	DYRK1A	S/T	✓	✓				✓
120	DYRK1B	S/T	✓	✓
121	DYRK2	S/T	✓	✓
122	DYRK3	S/T	✓	✓
123	DYRK4	S/T	✓	✓
124	EEF2K (eEF2K)	S/T	✓	✓
125	EGFR (ERBB1)	Y	✓	✓	✓			✓
126	EGFR (ERBB1)	Y	✓				✓
127	EGFR [C797S/L858R]	Y	✓				✓
128	EGFR [d746‐750/C797S/T790M]	Y	✓				✓
129	EGFR [d746‐750/C797S]	Y	✓				✓
130	EGFR [d746‐750/T790M]	Y	✓				✓
131	EGFR [d746‐750]	Y	✓				✓
132	EGFR [L858R]	Y	✓				✓
133	EGFR [L861Q]	Y	✓				✓
134	EGFR [T790M/C797S/L858R]	Y	✓				✓
135	EGFR [T790M/L858R]	Y	✓				✓
136	EGFR [T790M]	Y	✓				✓
137	EIF2AK1 (HRI)	S/T	✓	✓
138	EIF2AK2 (PKR)	S/T	✓	✓
139	EIF2AK3 (PERK/PEK)	S/T	✓	✓
140	EIF2AK4 (GCN2)	S/T	✓	✓
141	EPHA1	Y	✓	✓	✓
142	EPHA2	Y	✓	✓	✓
143	EPHA3	Y	✓	✓	✓
144	EPHA4	Y	✓	✓	✓
145	EPHA5	Y	✓	✓	✓			✓
146	EPHA6	Y	✓	✓	✓
147	EPHA7	Y	✓	✓	✓
148	EPHA8	Y	✓	✓	✓
149	EPHB1	Y	✓	✓	✓
150	EPHB2	Y	✓	✓	✓			✓
151	EPHB3	Y	✓	✓	✓
152	EPHB4	Y	✓	✓	✓
153	ERBB2 (HER2)	Y	✓	✓	✓
154	ERBB2 (HER2) [A775/G776insYVMA]	Y	✓				✓
155	ERBB4 (HER4)	Y	✓	✓	✓
156	ERN1 (IRE1)	S/T	✓	✓
157	ERN1 [R727A/R728A]	S/T	✓				✓
158	ERN1 [R727A]	S/T	✓				✓
159	ERN1 [R728A]	S/T	✓				✓
160	ERN2 (IRE2)	S/T	✓	✓
161	FAM20C	S/T	✓	✓
162	FER	Y	✓	✓	✓
163	FES	Y	✓	✓	✓
164	FGFR1	Y	✓	✓	✓			✓
165	FGFR2	Y	✓	✓	✓			✓
166	FGFR3	Y	✓	✓	✓
167	FGFR3 [G697C]	Y	✓				✓
168	FGFR3 [K650E]	Y	✓				✓
169	FGFR3 [K650M]	Y	✓				✓
170	FGFR3 [V555L]	Y	✓				✓
171	FGFR3 [V555M]	Y	✓				✓
172	FGFR4	Y	✓	✓	✓
173	FGR	Y	✓	✓	✓
174	FLT1 (VEGFR1)	Y	✓	✓	✓			✓
175	FLT3	Y	✓	✓	✓			✓
176	FLT4 (VEGFR3)	Y	✓	✓	✓
177	FRK	Y	✓	✓	✓
178	FYNa (FYN)	Y	✓	✓	✓
179	FYNb (FYN)	Y	✓	✓	✓
180	GAK	S/T	✓	✓
181	GRK1 (RHOK)	S/T	✓	✓
182	GRK2 (ADRBK1, BARK1)	S/T	✓	✓
183	GRK3 (ADRBK2, BARK2)	S/T	✓	✓
184	GRK4 (GPRK4)	S/T	✓	✓
185	GRK5 (GPRK5)	S/T	✓	✓
186	GRK6 (GPRK6)	S/T	✓	✓
187	GRK7 (GPRK7)	S/T	✓	✓
188	GSK3A (GSK3α)	S/T	✓	✓
189	GSK3B (GSK3β)	S/T	✓	✓				✓
190	HASPIN	S/T	✓	✓
191	HCK	Y	✓	✓	✓
192	HIPK1	S/T	✓	✓
193	HIPK2	S/T	✓	✓				✓
194	HIPK3	S/T	✓	✓
195	HIPK4	S/T	✓	✓
196	HUNK	S/T	✓	✓
197	ICK	S/T	✓	✓
198	IGF1R	Y	✓	✓	✓			✓
199	IKKB (IKKβ)	S/T	✓	✓
200	IKKE (IKKe)	S/T	✓	✓				✓
201	INSR (IR)	Y	✓	✓	✓			✓
202	INSRR (IRR)	Y	✓	✓	✓
203	IRAK1	S/T	✓	✓
204	IRAK4	S/T	✓	✓				✓
205	ITK	Y	✓	✓	✓
206	JAK1 [JH1]	Y	✓	✓	✓
207	JAK1 [JH1-JH2]	Y	✓	✓	✓
208	JAK2 [JH1]	Y	✓	✓	✓			✓
209	JAK2 [JH1-JH2]	Y	✓	✓	✓
210	JAK3 [JH1]	Y	✓	✓	✓
211	KDR (VEGFR2)	Y	✓	✓	✓			✓
212	KIT (SCFR, CD117)	Y	✓	✓	✓			✓
213	LATS1	S/T	✓	✓
214	LATS2	S/T	✓	✓
215	LCK	Y	✓	✓	✓			✓
216	LIMK1	S/T	✓	✓				✓
217	LIMK2	S/T	✓	✓
218	LRRK2	S/T	✓	✓				✓
219	LRRK2 [G2019S]	S/T	✓				✓
220	LRRK2 [R1441G]	S/T	✓				✓
221	LRRK2 [R1441H]	S/T	✓				✓
222	LTK	Y	✓	✓	✓
223	LYNA (LYNa)	Y	✓	✓	✓			✓
224	LYNB (LYNb)	Y	✓	✓	✓
225	MAK	S/T	✓	✓
226	MAP2K1 (MEK1)	S/T	✓	✓				✓
227	MAP2K2 (MEK2)	S/T	✓	✓
228	MAP2K3 (MEK3)	S/T	✓	✓
229	MAP3K1 (MEKK1)	S/T	✓	✓				✓
230	MAP3K2 (MEKK2)	S/T	✓	✓
231	MAP3K3 (MEKK3)	S/T	✓	✓
232	MAP3K5 (ASK1)	S/T	✓	✓
233	MAP3K6 (ASK2)	S/T	✓	✓
234	MAP3K7 (TAK1)	S/T	✓	✓
235	MAP3K8 (COT, Tpl2)	S/T	✓	✓
236	MAP3K9 (MLK1)	S/T	✓	✓
237	MAP3K10 (MLK2)	S/T	✓	✓
238	MAP3K11 (MLK3)	S/T	✓	✓
239	MAP3K12 (DLK)	S/T	✓	✓
240	MAP3K13 (LZK)	S/T	✓	✓
241	MAP3K14 (NIK)	S/T	✓	✓
242	MAP3K19 (YSK4)	S/T	✓	✓
243	MAP3K20 (MLK7, ZAK)	S/T	✓	✓
244	MAP3K21 (MLK4)	S/T	✓	✓
245	MAP4K1 (HPK1)	S/T	✓	✓
246	MAP4K2 (GCK)	S/T	✓	✓
247	MAP4K3 (GLK, KHS2)	S/T	✓	✓
248	MAP4K4 (HGK, ZC1)	S/T	✓	✓
249	MAP4K5 (KHS1)	S/T	✓	✓
250	MAPK1 (ERK2)	S/T	✓	✓
251	MAPK3 (ERK1)	S/T	✓	✓
252	MAPK7 (BMK, ERK5)	S/T	✓	✓
253	MAPK8 (JNK1)	S/T	✓	✓
254	MAPK9 (JNK2)	S/T	✓	✓
255	MAPK10 (JNK3)	S/T	✓	✓
256	MAPK11 (p38β)	S/T	✓	✓
257	MAPK12 (p38γ)	S/T	✓	✓
258	MAPK13 (p38δ)	S/T	✓	✓
259	MAPK14 (p38α)	S/T	✓	✓
260	MAPK15 (ERK7)	S/T	✓	✓
261	MAPKAPK2 (MK2)	S/T	✓	✓
262	MAPKAPK3 (MK3)	S/T	✓	✓
263	MAPKAPK5 (MK5)	S/T	✓	✓
264	MARK1	S/T	✓	✓
265	MARK2	S/T	✓	✓
266	MARK3	S/T	✓	✓
267	MARK4	S/T	✓	✓
268	MAST3	S/T	✓	✓
269	MASTL	S/T	✓	✓
270	MATK (CTK)	Y	✓	✓	✓
271	MELK	S/T	✓	✓
272	MERTK (MER)	Y	✓	✓	✓
273	MET (c-MET, HGFR)	Y	✓	✓	✓			✓
274	MET [Y1230H]	Y	✓				✓
275	MINK1 (MAP4K6, MINK, ZC3)	S/T	✓	✓
276	MKNK1 (MNK1)	S/T	✓	✓
277	MKNK2 (MNK2)	S/T	✓	✓				✓
278	MST1R (RON)	Y	✓	✓	✓
279	mTOR (FRAP)	S/T	✓	✓
280	MUSK	Y	✓	✓	✓
281	MYLK (smMLCK)	S/T	✓	✓
282	MYLK2 (skMLCK)	S/T	✓	✓
283	MYLK3 (caMLCK)	S/T	✓	✓				✓
284	MYLK4 (SgK085)	S/T	✓	✓
285	MYO3A	S/T	✓	✓
286	MYO3B	S/T	✓	✓
287	NEK1	S/T	✓	✓				✓
288	NEK2	S/T	✓	✓
289	NEK3	S/T	✓	✓
290	NEK4	S/T	✓	✓
291	NEK5	S/T	✓	✓
292	NEK6	S/T	✓	✓
293	NEK7	S/T	✓	✓
294	NEK8	S/T	✓	✓
295	NEK9	S/T	✓	✓
296	NEK10	S/T	✓	✓
297	NEK11	S/T	✓	✓
298	NIM1 (NIM1K)	S/T	✓	✓
299	NLK (LAK1)	S/T	✓	✓
300	NTRK1 (TRKA)	Y	✓	✓	✓			✓
301	NTRK2 (TRKB)	Y	✓	✓	✓
302	NTRK3 (TRKC)	Y	✓	✓	✓
303	NUAK1 (ARK5)	S/T	✓	✓				✓
304	NUAK2 (SNARK)	S/T	✓	✓
305	PAK1	S/T	✓	✓
306	PAK2	S/T	✓	✓
307	PAK3	S/T	✓	✓
308	PAK4	S/T	✓	✓				✓
309	PAK5 (PAK7)	S/T	✓	✓
310	PAK6	S/T	✓	✓
311	PASK	S/T	✓	✓
312	PBK (TOPK)	S/T	✓	✓
313	PDGFRA (PDGFRα)	Y	✓	✓	✓
314	PDGFRB (PDGFRβ)	Y	✓	✓	✓
315	PDK1 (PDHK1)	S/T	✓	✓				✓
316	PDK2 (PDHK2)	S/T	✓	✓
317	PDK3 (PDHK3)	S/T	✓	✓
318	PDK4 (PDHK4)	S/T	✓	✓
319	PDPK1 (PDK1)	S/T	✓	✓
320	PHKG1	S/T	✓	✓
321	PHKG2	S/T	✓	✓
322	PIM1	S/T	✓	✓
323	PIM2	S/T	✓	✓
324	PIM3	S/T	✓	✓				✓
325	PINK1 (PINK)	S/T	✓	✓
326	PKN1	S/T	✓	✓
327	PKN2	S/T	✓	✓
328	PKN3	S/T	✓	✓
329	PLK1	S/T	✓	✓				✓
330	PLK2	S/T	✓	✓
331	PLK3	S/T	✓	✓
332	PLK4	S/T	✓	✓
333	PNCK (CAMK1β)	S/T	✓	✓
334	PRKAA1‐B1‐G1 (AMPKα1β1γ1)	S/T	✓	✓
335	PRKAA1-B1-G2 (AMPKα1β1γ2)	S/T	✓	✓
336	PRKAA1-B1-G3 (AMPKα1β1γ3)	S/T	✓	✓
337	PRKAA1‐B2‐G1 (AMPKα1β2γ1)	S/T	✓	✓
338	PRKAA1-B2-G2 (AMPKα1β2γ2)	S/T	✓	✓
339	PRKAA1-B2-G3 (AMPKα1β2γ3)	S/T	✓	✓
340	PRKAA2‐B1‐G1 (AMPKα2β1γ1)	S/T	✓	✓
341	PRKAA2-B1-G2 (AMPKα2β1γ2)	S/T	✓	✓
342	PRKAA2-B1-G3 (AMPKα2β1γ3)	S/T	✓	✓
343	PRKAA2‐B2‐G1 (AMPKα2β2γ1)	S/T	✓	✓
344	PRKAA2-B2-G2 (AMPKα2β2γ2)	S/T	✓	✓
345	PRKAA2-B2-G3 (AMPKα2β2γ3)	S/T	✓	✓
346	PRKACA (PKACα)	S/T	✓	✓				✓
347	PRKACB (PKACβ)	S/T	✓	✓
348	PRKACG (PKACG, PKACg)	S/T	✓	✓
349	PRKCA (PKCα)	S/T	✓	✓				✓
350	PRKCB1 (PKCβ1)	S/T	✓	✓
351	PRKCB2 (PKCβ2)	S/T	✓	✓
352	PRKCD (PKCδ)	S/T	✓	✓
353	PRKCE (PKCe)	S/T	✓	✓
354	PRKCG (PKCγ)	S/T	✓	✓
355	PRKCH (PKCη)	S/T	✓	✓
356	PRKCI (PKCι)	S/T	✓	✓
357	PRKCQ (PKCᶿ)	S/T	✓	✓				✓
358	PRKCZ (PKCζ)	S/T	✓	✓
359	PRKD1 (PKD1)	S/T	✓	✓
360	PRKD2 (PKD2)	S/T	✓	✓
361	PRKD3 (PKD3)	S/T	✓	✓
362	PRKDC (DNA‐PK)	S/T	✓	✓
363	PRKG1 (PKG1, PGK)	S/T	✓	✓
364	PRKG2 (PKG2, PGK2, CGK2)	S/T	✓	✓
365	PRKX	S/T	✓	✓
366	PTK2 (FAK)	Y	✓	✓	✓			✓
367	PTK2B (PYK2)	Y	✓	✓	✓
368	PTK6 (BRK)	Y	✓	✓	✓
369	RAF1 [Y340E/Y341E]	S/T	✓				✓
370	RAF1 [Y340E/Y341E]	S/T	✓				✓
371	RET	Y	✓	✓	✓			✓
372	RET [G691S]	Y	✓				✓
373	RET [M918T]	Y	✓				✓
374	RET [S891A]	Y	✓				✓
375	RET [Y791F]	Y	✓				✓
376	RET:CCDC6 (CCDC6‐RET)	Y	✓				✓
377	RIPK1	S/T	✓	✓
378	RIPK2	S/T	✓	✓
379	RIPK3	S/T	✓	✓
380	RIPK4 (ANKRD3)	S/T	✓	✓
381	ROCK1	S/T	✓	✓				✓
382	ROCK2	S/T	✓	✓				✓
383	ROS1 (ROS)	Y	✓	✓	✓
384	ROS1 [G2032R]	Y	✓				✓
385	RPS6KA1 (RSK1)	S/T	✓	✓				✓
386	RPS6KA2 (RSK3)	S/T	✓	✓
387	RPS6KA3 (RSK2)	S/T	✓	✓
388	RPS6KA4 (MSK2)	S/T	✓	✓				✓
389	RPS6KA5 (MSK1)	S/T	✓	✓
390	RPS6KA6 (RSK4)	S/T	✓	✓
391	RPS6KB1 (p70S6K)	S/T	✓	✓
392	RPS6KB2 (p70S6KB)	S/T	✓	✓				✓
393	SBK1 (SBK)	S/T	✓	✓
394	SGK1 (SGK)	S/T	✓	✓
395	SGK2	S/T	✓	✓
396	SGK3	S/T	✓	✓
397	SIK1 (SIK)	S/T	✓	✓
398	SIK2 (QIK)	S/T	✓	✓
399	SIK3 (QSK)	S/T	✓	✓
400	SLK	S/T	✓	✓
401	SNRK	S/T	✓	✓
402	SRC	Y	✓	✓	✓			✓
403	SRMS (SRM)	Y	✓	✓	✓
404	SRPK1	S/T	✓	✓
405	SRPK2	S/T	✓	✓
406	SRPK3 (MSSK1)	S/T	✓	✓
407	STK3 (CLIK1, MST2)	S/T	✓	✓
408	STK4 (MST1)	S/T	✓	✓				✓
409	STK10 (LOK)	S/T	✓	✓				✓
410	STK11 (LKB1, AMPKK)	S/T	✓	✓
411	STK17A (DRAK1)	S/T	✓	✓
412	STK17B (DRAK2)	S/T	✓	✓
413	STK24 (MST3)	S/T	✓	✓
414	STK25 (YSK1)	S/T	✓	✓
415	STK26 (MST4)	S/T	✓	✓
416	STK33	S/T	✓	✓
417	STK38 (NDR1)	S/T	✓	✓
418	STK38L (NDR2)	S/T	✓	✓
419	SYK	Y	✓	✓	✓
420	TAOK1 (TAO1)	S/T	✓	✓
421	TAOK2 (TAO2)	S/T	✓	✓
422	TAOK3 (TAO3)	S/T	✓	✓
423	TBK1	S/T	✓	✓
424	TEC	Y	✓	✓	✓			✓
425	TEK (TIE2)	Y	✓	✓	✓
426	TESK2	S/T	✓	✓
427	TLK1	S/T	✓	✓
428	TLK2	S/T	✓	✓
429	TNIK (ZC2)	S/T	✓	✓
430	TNK1	Y	✓	✓	✓
431	TNK2 (ACK)	Y	✓	✓	✓
432	TRPM7 (CHAK1)	S/T	✓	✓
433	TSSK1B (TSSK1)	S/T	✓	✓				✓
434	TSSK2	S/T	✓	✓
435	TSSK3	S/T	✓	✓
436	TSSK6 (SSTK)	S/T	✓	✓
437	TTBK1	S/T	✓	✓
438	TTBK2	S/T	✓	✓
439	TTK	S/T	✓	✓
440	TXK	Y	✓	✓	✓
441	TYK2 [JH1]	Y	✓	✓	✓			✓
442	TYRO3	Y	✓	✓	✓
443	ULK1	S/T	✓	✓				✓
444	ULK2	S/T	✓	✓
445	ULK3	S/T	✓	✓
446	VRK1	S/T	✓	✓
447	VRK2	S/T	✓	✓
448	WEE1	S/T	✓	✓				✓
449	YES1 (YES)	Y	✓	✓	✓
450	ZAP70	Y	✓	✓	✓