Reaction Biologyでは、Biacore™ 8KおよびBiacore™ 8K+を用いてSurface Plasmon Resonance (SPR)アッセイサービスを提供しています。カイネティクスとアフィニティー(Kon, Koff, KD)の決定、Co-factorの有無での競合試験、抗体スクリーニング、SAR研究、血漿タンパク質結合の評価等、SPRアッセイは様々な課題に対応するツールとして有用なアッセイの一つです。

下記リストのターゲットについては、既に評価系を有しており、Assay Developmentのステップを経ることなく、試験物質の評価が可能です。リストにないターゲットについては、Assay Developmentからの対応となります。詳細はお問い合わせください。

Surface Plasmon Resonance Assays

Target nameSynonyms
1FCGRTFc gamma receptor & transporter; FcgammaRn; FcRn
2FCGR1AFc gamma receptor Ia; CD64; CD64A; FcgammaRI; FcgammaRIa; FCG1; FCGR1
3FCGR3AFc gamma receptor IIIa; CD16; CD16a; FcgammaRIIIa; FcGRIII
4FCGR3BFc gamma receptor IIIb; CD16; CD16b; FcgammaRIIIb; FcRIIIb
5FCGR2BFc gamma receptor Iib; CD32; CD32B; FcgammaRIIb; FcGRIIB
6FCGR2AFc gamma receptor IIa; CD32; CD32A; IGFR2; CDw32; Fc-gamma-RIIa; FcgammaRIIa
7SARS-CoV-2 S protein – ACE2 interactionSpike glycoprotein, receptor binding domain; Angiotensin I converting enzyme 2
8Cereblon CULT DomainMRT2, MRT2A
9ACE2Angiotensin I converting enzyme 2
10B-cell lymphoma-2BCL-2
11BCL-2 (G101V)
12BCL-2 (D103Y)
13BCL-2 (F104L)
14Bcl-2-like protein 1 isoform LBCL-XL
15Bcl-2-like protein 2BCLW, KIAA0271
16BPTF bromodomain
17BRD2-1O27.1.1, Really interesting new gene 3 protein
18BRD2-2O27.1.1, Really interesting new gene 3 protein
19BRD3-1RING3-like protein
20BRD3-2RING3-like protein
21BRD4-1Bromodomain containing 4, domain 1
22BRD4-2Bromodomain containing 4, domain 2
23BRD7 bromodomain
24BRD9 bromodomain
25BRDT-1Cancer/testis antigen 9, RING3-like protein
26c-Abl kinase domain
27cGASCyclic GMP-AMP synthase, fragment
28cGAS (aa 157-522)Cyclic GMP-AMP synthase, fragment
29CREB-binding proteinHistone lysine acetyltransferase CREBBP, Protein-lysine acetyltransferase CREBBP
30DHODHDihydroorotate dehydrogenase
31EEDPolycomb protein EED, embryonic ectoderm development
32EGFR: wildtype (aa 671-998)Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
33FGFR1 kinase domain
34FGFR2 kinase domain
35FGFR3 kinase domain
36G9aHistone-lysine N-methyltransferase EHMT2, Euchromatic histone-lysine N-methyltransferase 2, HLA-B-associated transcript 8, Histone H3-K9 methyltransferase 3 (H3-K9-HMTase 3), Lysine N-methyltransferase 1C
37H-RasHRAS, HRAS1
38Histone acetyltransferase p300EP300, p300
39Histone-lysine N-methyltransferase SETD2SET2
40KAT2A bromodomainHistone acetyltransferase KAT2A
41KAT2B bromodomainHistone acetyltransferase KAT2B
42K-RasC-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
43K-Ras (G12C)
44K-Ras (G12D)
45K-Ras (G12V)
46K-Ras (G12R)
47Mitogen-activated protein kinase 1MAPK1, ERT1, ERK2, MAPK 2
48N-RasNRAS, NRAS1
49NSD2-SETSET domain of NSD2
50Poly(ADP-ribose) glycohydrolasehPARG111
51Poly(ADP-ribose) glycohydrolase catalytic domain
52PRMT1Protein arginine N-methyltransferase 1
53PRMT5/MEP50Protein arginine methyltransferase 5, WD repeat domain 77
54SHP2Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D (PTP-1D), Protein-tyrosine phosphatase 2C (PTP-2C), SH-PTP2, SH-PTP3
55SMARCA2bBAF190B, BRM, SNF2L2
56SOS1SOS Ras/Rac guanine nucleotide exchange factor 1, son of sevenless homolog 1
57TEAD1transcription factor
58TEAD2transcription factor
59TEAD3transcription factor
60TEAD4transcription factor
61GNMTGlycine N-methyltransferase
62HNMTHistamine N-methyltransferase
63INMTIndolethylamine N-methyltransferase
64NNMTNicotinamide N-methyltransferase
65PNMTPhenylethanolamine N-methyltransferase
66TPMTThiopurine S-methyltransferase
67Cyclophilin APeptidylprolyl isomerase A
68VHL/EloB/EloCvon Hippel-Lindau tumor suppressor/Elongin B/Elongin C