PahrmaCore Labsでは、海馬皮質ニューロンやDRGニューロンを用いたマニュアルパッチクランプアッセイ、神経細胞のCaイメージングアッセイ等のニューロサイエンスアッセイの他、Cardiac safetyに関連するランゲンドルフ灌流アッセイやPurkinje fiberを用いたAction Potentialアッセイ、iPS細胞由来の心筋細胞等を用いたアッセイ等を提供しています。

Neuroscience Assays
Hippocampal,cortical neuron
Species: Neonatal Rat, mouse
Cell: Fresh isolated cell
Assay:Manual patch clmap
Experimental setting: 22℃, 3 dose n>10, 1 Hz stimulus
DRG exitanility
Species: Rat, mouse
Cell: Fresh isolated cell
Assay:Manual patch clmap
Experimental setting: 22℃, 3 dose n>10, 1 Hz stimulus
Neurons calcium imaging
Species: Rat, Guiea pig
Cell: Fresh isolated cell
Assay: Olympus microscope & Metaflour
Positive Controls: ISO 0.1 uM
Experimental setting: 22℃, 3 dose n>20, 1 Hz stimulus
CA1 pyramidal neurons, ion channels
Species: Rat, mouse
Cell: Slice
Assay:Manual patch clmap
Experimental setting: 22℃,
4 concentrations, n=6, 24 brain slices
Spinal Cord neurons, ion channels
Species: Rat, mouse
Cell: Slice
Assay:Manual patch clmap
Experimental setting: 22℃,
4 concentrations, n=6, 24 brain slices
Cardiac Assays
Langendorff isolated perfused heart
Species: Guinea pig, Rat, Mouse
Specimen: Isolated heart
Assay: Isolated heart perfusion
Positive Controls: Dofetilide
Test temperature 37℃
Experimental setting: 3 concentrations n=4
Isolated heart perfusion ECG & left ventricle pressure
Species: Guinea pig, Rat
Specimen: Isolated heart
Assay: Isolated heart perfusion
Positive Controls: Dofetilide
Test temperature 37℃
Experimental setting: 3 concentrations n=4
Purkinje Fiber action potential (AP)
Species: New Zealand rabbit
Specimen: Purkinje fiber
Assay: Intracellular action potential
Positive Controls: Dofetilide
Test temperature 37℃
Experimental setup: 3 concentrations n=4, 3 stimulation frequency
Myocytes action potential (AP)
Species: Guinea pig
Specimen: Fresh isolated Myocytes
Assay: Patch clamp
Positive Controls: Dofetilide
Test temperature 35-37℃
Experimental setup: 3 concentrations n=3, 1 stimulation frequency
Cardiac myocytes contractility
Species: Rat, Guinea pig
Cell: Ventricular / atrial myocytes
Assay: IonOptix
Positive Controls: ISO 0.1 uM
Experimental setting: 22℃, 3 dose n>3, 1 Hz stimulus
Cardiac myocytes transient Ca imagine
Species: Rat, Guinea pig
Cell: Ventricular / atrial myocytes
Assay: IonOptix
Positive Controls: ISO 0.1 uM
Experimental setting: 22℃, 3 dose n>3, 1 Hz stimulus
iPS cell screening platform
hiPS MC action potential
Species: Human origin
Cell: iPS CM
Assay: Manual patch clamp
Positive Controls: Dofetilide
Experimental setting: 33℃, 3 dose n=4, single stimulus
hiPS DRG / hiPS SN excitability & IC
Species: Human origin
Cell: Sensory neuron, DRG
Assay: Manual patch clamp
Experimental setting: 3 dose n=4
Nav1.5 fast channel
Species: Human origin
Cell: iPS CM
Assay: Manual patch clamp
Positive Controls: Flecainide
L-type Ca channel
Species: Human origin
Cell: iPS CM
Assay: Manual patch clamp
Positive Controls: Verapamil
Ik channel
Species: Human origin
Cell: iPS CM
Assay: Manual patch clamp
Positive Controls: Cisapride