Cell-base Assay - GPCR Functional Assays

Epics Therapeutics (former Euroscreen)のEuroscreenFASTでは、Aequorin (カルシウム)、cAMP、GTPγS、IPOne等の様々なアッセイ方法により、GPCR functional Assayが可能です。アゴニスト及びアンタゴニスト活性の測定の他、PAMやNAMの測定も実施しております。様々な種もラインナップされておりますので、種差の検証にも有用です。また、Radioligand bindingアッセイも提供しておりますので、Functional assayと組み合わせての利用も可能です。

FAMILY	RECEPTOR	SPECIES	Aequorin	cAMP	IPOne	GTPgS	Radioligand binding	ERK1/2	Internalisation
Adenosine	A1	HS	FAST-001A	FAST-001C		FAST-001G	FAST-001B
		MM		FAST-031C		FAST-031G	FAST-031B
		CF		FAST-0165C			FAST-0165B
		RN		FAST-0162C			FAST-0162B
	A2A	HS	FAST-002A	FAST-002C		FAST-002G	FAST-002B
		MM		FAST-032C			FAST-032B
		RN		FAST-0163C			FAST-0163B
		CF		FAST-0166C			FAST-0166C
	A2B	HS	FAST-003A	FAST-003C			FAST-003B
		MM		FAST-033C			FAST-033B
		RN		FAST-0164C
		CF		FAST-0167C
	A3	HS	FAST-004A	FAST-004C		FAST-004G	FAST-004B
		MM		FAST-034C		FAST-034G	FAST-034B
		RN		FAST-012C		FAST-012G	FAST-012B
		CF		FAST-0168C
Adrenergic	a1A	HS	FAST-005A	FAST-005C	FAST-005I		FAST-005B
	a1B	HS	FAST-008A		FAST-008I		FAST-008B
	a1D	HS	FAST-009A		FAST-009I		FAST-009B
	a2A	HS	FAST-006A	FAST-006C		FAST-006G	FAST-006B
	a2B	HS	FAST-007A			FAST-007G	FAST-007B
		CF	FAST-013A			FAST-013G	FAST-013B
	a2C	HS	ES-032A	ES-032C		ES-032G	ES-032B
	b1	HS	ES-033A	ES-033C			ES-033B
	b2	HS		ES-034C			ES-034B
	b3	HS	ES-035A	ES-035C			ES-035B
Anaphylotaxin	C3a	HS	FAST-010A	FAST-010C		FAST-010G	FAST-010B
	C5a	HS		FAST-011C		FAST-011G
	C5a2 (C5AR2/GPR77)	HS					FAST-0960B
Angiotensin	AT1	HS	FAST-015A		FAST-015I		FAST-015B
		CF					FAST-037B
	AT2	HS					FAST-016B
		MM					FAST-017B
		CF					FAST-038B
Apelin	APJ	HS	FAST-020A	FAST-020C		FAST-020G	FAST-020B
Bile Acid	GPBA (TGR5/GPR131)	HS		FAST-0965C
		CF		FAST-0966C
		MM		FAST-0967C
		RN		FAST-0968C
Bombesin	BB1	HS	FAST-022A				FAST-022B
	BB2	HS	FAST-023A				FAST-023B
	BB3	HS	FAST-021A				FAST-021B
		MM	FAST-018***
		RN	FAST-019***
Bradykinin	B1	HS	FAST-027A		FAST-027I		FAST-027B
		RN	FAST-0207A
	B2	HS	FAST-028A				FAST-028B
Calcitonin	CGRP (CRLR/RAMP1)	HS	FAST-025A	FAST-025C			FAST-025B
		MM		FAST-054C
		RN		FAST-055C
	AM1 (CRLR/RAMP2)	HS		FAST-026C
	AM2 (CRLR/RAMP3)	HS	FAST-024A	FAST-024C			FAST-024B
	AMY1 (CTR/RAMP1)	HS		FAST-035C
	AMY2 (CTR/RAMP2)	HS		FAST-036C
	AMY3 (CTR/RAMP3)	HS		FAST-029C			FAST-029B
	CTR	HS		FAST-030C
Calcium	CaS	HS	FAST-0680A		FAST-0680I
Cannabinoid	CB1	HS		FAST-040C		FAST-040G	FAST-040B	FAST-040E
		RN		FAST-044C		FAST-044G	FAST-044B
		MF		FAST-042C
		OC		FAST-046C
	CB2	HS		FAST-041C		FAST-041G	FAST-041B
		RN		FAST-045C		FAST-045G	FAST-045B
Chemerin	CCRL2	HS					FAST-0948B
	CMKLR1 (ChemR23)	HS	FAST-050A	FAST-050C		FAST-050G	FAST-050B	FAST-050E
	CMKLR1 (ChemR23)	RN	FAST-053A
	CMKLR1 (DEZ)	MM	FAST-051A				FAST-051B
	GPR1	HS					FAST-052B
Chemokine	CCR1	HS	FAST-058A	FAST-058C		FAST-058G	FAST-058B
		MM		FAST-059C
	CCR2b	HS	FAST-060A	FAST-060C		FAST-060G	FAST-060B
		MM	FAST-0600A	FAST-0600C			FAST-0600B
		RN	FAST-0616A	FAST-0616C			FAST-0616B
		RH	FAST-0710A				FAST-0710B
	CCR3	HS	FAST-061A			FAST-061G	FAST-061B
		MM	FAST-0601A
	CCR4	HS	FAST-069A	FAST-069C		FAST-069G	FAST-069B
		MM	FAST-0602A
	CCR5*	HS	FAST-062A	FAST-062C		FAST-062G	FAST-062B	FAST-062E
		MM	FAST-0603A	FAST-0603C			FAST-0603B
		RN	FAST-0617A	FAST-0617C			FAST-0617B
		CF	FAST-0712A
		RH	FAST-0711A	FAST-0711C			FAST-0711B
		OC	FAST-0713A
	CCR6	HS	FAST-063A	FAST-063C		FAST-063G	FAST-063B
		MM	FAST-0604A	FAST-0604C
	CCR7	HS	FAST-064A	FAST-064C		FAST-064G	FAST-064B	FAST-064E
		MM	FAST-0605A
	CCR8	HS	FAST-065A		FAST-065C	FAST-065G	FAST-065B
		MM	FAST-0606A		FAST-0606C
	CCR9a	HS	FAST-066A
		MM	FAST-0607A
	CCR10	HS	FAST-067A	FAST-067C		FAST-067G
		MM	FAST-0608A
	CXCR1	HS	FAST-071A	FAST-071C		FAST-071G	FAST-071B
		MM	FAST-0609A
	CXCR2	HS	FAST-075A	FAST-075C		FAST-075G	FAST-075B
		MM	FAST-0610A
	CXCR3a	HS	FAST-076A			FAST-076G	FAST-076B
		MM	FAST-0611A
	CXCR3b	HS	FAST-0761A
	CXCR4	HS	FAST-077A	FAST-077C		FAST-077G	FAST-077B
		MM	FAST-0612A
		RN	FAST-0619A
	CXCR5	HS	FAST-078A			FAST-078G
		MM	FAST-0613A
	CXCR6	HS	FAST-080A	FAST-080C		FAST-080G
		MM	FAST-0614A
	CXCR7	HS					FAST-081B
	CX3CR1	HS	FAST-070A	FAST-070C		FAST-070G	FAST-070B	FAST-070E
		MM	FAST-0615A			FAST-0615G
		RN	FAST-0618A
	XCR1	HS	FAST-085A	FAST-085C		FAST-085G
Cholecystokinin	CCK1	HS	FAST-090A	FAST-090C	FAST-090I		FAST-090B
	CCK2	HS	FAST-091A		FAST-091I		FAST-091B
Corticotropin-releasing factor	CRF1	HS	FAST-095A	FAST-095C		FAST-095G	FAST-095B
	CRF2a	HS		FAST-097C
		RN		FAST-098C
		CF		FAST-094C
	CRF2b	HS		FAST-096C			FAST-096B
Dopamine	D1	HS		FAST-0100C			FAST-0100B
		RN		FAST-0126C
	D2L	HS	FAST-0101A	FAST-0101C		FAST-0101G	FAST-0101B
	D2S	HS	FAST-0102A	FAST-0102C		FAST-0102G	FAST-0102B
		MM		FAST-0132C
		RN		FAST-0127C
	D3	HS				ES-173G	ES-173B
	D4.4	HS		FAST-099C		FAST-099G	FAST-099B
		RN				FAST-0103G	FAST-0103B
	D5	HS		FAST-0104C
		RN		FAST-0129C
Endothelin	ETA	HS	FAST-0105A				FAST-0105B
		RN	FAST-0107A
	ETB	HS	FAST-0106A				FAST-0106B
		RN	FAST-0108A
Formylpeptide	FPR1 (fMLP)	HS	FAST-0342A	FAST-0342C
		MM		FAST-0345C
		OC		FAST-0339C
	FPR2 (FPRL1)	HS	FAST-0340A	FAST-0340C		FAST-0340G	FAST-0340B
		MM		FAST-0343C
		RN		FAST-0344C
		CF		FAST-0347C
		OC		FAST-0348C
		MF		FAST-0349C
	FPR3 (FPRL2)	HS	FAST-0341A	FAST-0341C
Free fatty acid	FFA1 (GPR40)	HS	FAST-0110A		FAST-0110I
		MM	FAST-0109A
	FFA3 (GPR41)	HS	FAST-0111A	FAST-0111C		FAST-0111G
		MM		FAST-0118C
	FFA2 (GPR43)*	HS	FAST-0112A	FAST-0112C	FAST-0112I	FAST-0112G		FAST-0112E
		MM	FAST-0116A	FAST-0116C	FAST-0116I	FAST-0116G
		RN	FAST-0117A	FAST-0117C	FAST-0117I	FAST-0117G
		RH	FAST-0124A	FAST-0124C
		CF	FAST-0123A	FAST-0123C
		SS				FAST-0125G
	GPR35	HS	FAST-0915A	FAST-0915C		FAST-0915G		FAST-0915E
		MM	FAST-0991A	FAST-0991C
		RN	FAST-0992A	FAST-0992C
	GPR84	HS	FAST-0935A	FAST-0935C		FAST-0935G		FAST-0935E	FAST-0935T
		MM	FAST-0993A	FAST-0993C
		RN	FAST-0994A	FAST-0994C
	FFA4 (GPR120)	HS	FAST-0113A		FAST-0113I			FAST-0113E
		MM	FAST-0114A
		RN	FAST-0115A
GABA	GABA B1a/B2	HS	FAST-0120A	FAST-0120C		FAST-0120G	FAST-0120B
	GABA B1b/B2	HS		FAST-0122C
	GABA (non-selective)	RN					FAST-0121B
Galanin	GAL1	HS	FAST-0130A	FAST-0130C		FAST-0130G	FAST-0130B
	GAL2	HS	FAST-0131A		FAST-0131I	FAST-0131G	FAST-0131B
Ghrelin	GHS-R	HS	FAST-0135A		FAST-0135I		FAST-0135B
Glucagon	Glucagon	HS	FAST-0138A	FAST-0138C			FAST-0138B
		MM		FAST-0137C
	GIP	HS	FAST-0139A	FAST-0139C			FAST-0139B		FAST-0139T
	GLP-1	HS	FAST-0145A	FAST-0145C			FAST-0145B		FAST-0145T
		MM		FAST-0147C			FAST-0147B		FAST-0147T
	GLP-2	HS		FAST-0146C
	GHRHR	HS		FAST-0160C
	Secretin	HS	FAST-0161A	FAST-0161C
Glutamate (metabotropic)	mGlu1	HS	FAST-0152A	FAST-0152C			FAST-0152B
	mGlu2	HS		FAST-0153C
	mGlu3	HS	FAST-0155A
	mGlu4	HS		FAST-0150C		FAST-0150G
	mGlu5	HS	FAST-0151A		FAST-0151I		FAST-0151B
		RN					FAST-0158B
	mGlu6	HS				FAST-0157G
	mGlu7	HS		FAST-0154C
	mGlu8	HS				FAST-0156G
Glycoprotein hormone	FSH	HS		FAST-0580C
	LH	HS		FAST-0581C
	TSH	HS		FAST-0582C
		MM		FAST-0584C
		RN		FAST-0585C
GnRH	GnRHR1	HS	FAST-0583A				FAST-0583B
GPR/Orphan	GPR3	HS		FAST-0700C***
		MM		FAST-0703C***
		RN		FAST-0704C***
	GPR6	HS		FAST-0701C***
	GPR12	HS		FAST-0702C***
	GPR17	HS	FAST-0903A	FAST-0903C	FAST-0903I	FAST-0903G			FAST-0903T
	GPR17long	HS	FAST-0996A	FAST-0996C	FAST-0996I	FAST-0996G
	GPR17	MM	FAST-0997A	FAST-0997C	FAST-0997I	FAST-0997G
	GPR17	RN	FAST-0998A	FAST-0998C	FAST-0998I	FAST-0998G
	GPR18	HS	FAST-0904***
	GPR19 (GPR-NGA)	HS	FAST-0905***
	GPR20	HS	FAST-0906***
	GPR21	HS		FAST-0907C***
	GPR22	HS	FAST-0908***
	GPR23 (LPAR4)	HS	FAST-0640***
	GPR25	HS	FAST-0909***
	GPR26	HS		FAST-0970C***
	GPR27 (SREB1)	HS	FAST-0910***
	GPR30 (GPER)	HS	FAST-0911A
		MM	FAST-0886A
		RN	FAST-0887A
	GPR31	HS	FAST-0912***
	GPR32	HS	FAST-0913***
	GPR37	HS	FAST-0916***
	GPR37L1	HS	FAST-0917***
	GPR39	HS	FAST-0918A	FAST-0918C
		MM	FAST-0932A	FAST-0932C
		RN		FAST-0999C
	GPR45	HS	FAST-0919***
	GPR50	HS	FAST-0920***
	GPR52	HS		FAST-0921C
		MM		FAST-0891C
		RN		FAST-0961C
	GPR61	HS		FAST-0924C***
	GPR63	HS	FAST-0925***
	GPR75	HS	FAST-0930***
	GPR78	HS		FAST-0931C***
	GPR82	HS	FAST-0933***
	GPR83 (GPR72)	HS	FAST-0934A		FAST-0934I
		MM	FAST-0945A		FAST-0945I
	GPR87 (HG03)	HS	FAST-0937***
	GPR88*	HS	FAST-0938A	FAST-0938C
		MM		FAST-0963C
		RN		FAST-0964C
	GPR101	HS		FAST-0941C***
		MM		FAST-0953C***
		RN		FAST-0954C***
	GPR132 (G2A)	HS	FAST-0967***
	GPR139	HS	FAST-0980A
	GPR141	HS	FAST-0981***
	GPR142	HS			FAST-0969I
		MM			FAST-0898I
		RN			FAST-0899I
	GPR142 long isoform	MM			FAST-0896I
		RN			FAST-0897I
	GPR146	HS	FAST-0976***
	GPR148	HS	FAST-0982***
	GPR149	HS	FAST-0983***
	GPR150	HS	FAST-0984***
	GPR151	HS	FAST-0985***
	GPR152	HS	FAST-0942***
	GPR153	HS	FAST-0978***
	GPR161 (RE2)	HS		FAST-0962C***
	GPR162 (A-2)	HS	FAST-0943***
	GPR173 (SREB3)	HS	FAST-0977***
	GPR174 (DA6)	HS	FAST-0944***
	GPR171 (H963)	HS	FAST-0946***
	GPR176 (HB954)	HS	FAST-0947***
	GPR182 (HSGPCP)	HS	FAST-0949***
	GPRC5A (RAIG1)	HS	FAST-0955***
	GPRC5B (RAIG2)	HS	FAST-0956***
	GPRC5C (RAIG3)	HS	FAST-0957***
	GPRC5D (RAIG4)	HS	FAST-0958***
	LGR4	HS	FAST-0972***
	LGR5	HS	FAST-0973***
	LGR6	HS	FAST-0974***
	P2Y5	HS	FAST-0950***
	P2Y8	HS	FAST-0986A
	P2Y10	HS	FAST-0951***
Histamine	H1	HS	FAST-0170A		FAST-0170I		FAST-0170B
	H2	HS	FAST-0171A	FAST-0171C			FAST-0171B
	H3*	HS	FAST-0172A	FAST-0172C		FAST-0172G	FAST-0172B
		RN				FAST-0174G	FAST-0174B
		CF				FAST-0175G
	H4	HS	FAST-0173A			FAST-0173G	FAST-0173B
		MM				FAST-0169G
Hydroxycarboxylic acid	GPR109a (HM74a/HCA2)	HS	FAST-0350A	FAST-0350C		FAST-0350G	FAST-0350B
	GPR109b (HM74/HCA3)	HS	FAST-0351A	FAST-0351C		FAST-0351G		FAST-0351E
	GPR81 (HCA1)	HS	FAST-0352A	FAST-0352C		FAST-0352G
		MM		FAST-0353C
		RN		FAST-0354C
KiSS1/Kisspeptin	GPR54 (KiSS1)	HS	FAST-0180A				FAST-0180B
		RN	FAST-0181A
Leukotriene	BLT1 (LTB4R)	HS	FAST-0192A			FAST-0192G
	BLT2 (LTB4R2)	HS	FAST-0194A
	CysLT1	HS	FAST-0190A				FAST-0190B
	CysLT2*	HS	FAST-0191A		FAST-0191I		FAST-0191B
	OXE (HM74like)	HS	FAST-0193A
Lysophospholipids	LPA3 (EDG7)	HS	FAST-0632A		FAST-0632I
	LPA5 (GPR92)	HS			FAST-0641I
	GPR34	HS	FAST-0914A	FAST-0914C		FAST-0914G
	GPR55	HS	FAST-0922A						FAST-0922T
Mas related	MrgX1	HS	FAST-0213A
	MrgX2	HS	FAST-0214A
	MAS	HS	FAST-0210A
	MRG	HS	FAST-0211**
	MRGD (TGR7)	HS	FAST-0212A	FAST-0212C		FAST-0212G
	MRGE	HS	FAST-0216***
	MRGF (RTA)	HS	FAST-0215***
Melanin	MCH1	HS	FAST-0220A	FAST-0220C		FAST-0220G	FAST-0220B
concentrating		MM	FAST-0660A
hormone	MCH2	HS	FAST-0221A				FAST-0221B
Melanocortin	MC1	HS		FAST-0230C			FAST-0230B
		RN		FAST-0224C
		SS		FAST-0225C
	MC2 (MC2/MRAP)	HS	FAST-0231A	FAST-0231C
		RN		FAST-0226C
	MC3	HS		FAST-0232C			FAST-0232B
		MM		FAST-0235C
		RN		FAST-0227C
		SS		FAST-0228C
	MC4	HS		FAST-0233C	FAST-0233I		FAST-0233B
		RN		FAST-0229C
	MC5	HS		FAST-0234C			FAST-0234B
		MM		FAST-0236C			FAST-0236B
		RN		FAST-0237C			FAST-0237B
		CF		FAST-0238C			FAST-0238B
Melatonin	MT1	HS	FAST-0240A			FAST-0240G	FAST-0240B
	MT2	HS	FAST-0241A			FAST-0241G	FAST-0241B
Motilin	MTL	HS	FAST-0250A		FAST-0250I		FAST-0250B
Muscarinic	M1	HS	FAST-0260A		FAST-0260I	FAST-0260G	FAST-0260B
		RN	FAST-0262A
	M2	HS	FAST-0261A	FAST-0261C		FAST-0261G	FAST-0261B
		RN	FAST-0263A
	M3	HS	ES-212A		ES-212I		ES-212B
		RN	FAST-0266A
	M4	HS	ES-213A			ES-213G	ES-213B
		RN	FAST-0267A
	M5	HS	FAST-0264A		FAST-0264I		FAST-0264B
		RN	FAST-0268A
	Non-selective	RN					FAST-0265B
Neurokinin	NK1	HS	FAST-0269A				FAST-0269B
		MM	FAST-0621A				FAST-0621B
		RN	FAST-0622A				FAST-0622B
		RH	FAST-0634A
	NK2	HS	FAST-0270A				FAST-0270B
		MM	FAST-0623A
		RN	FAST-0624A
		RH	FAST-0635A
Neuromedin U	NMU-1R (FM3)	HS	FAST-0280A		FAST-0280I		FAST-0280B
		MM			FAST-0282I
	NMU-2R (FM4)	HS	FAST-0281A		FAST-0281I		FAST-0281B
		MM			FAST-0283I		FAST-0283B
Neuropeptide	NPY1	HS	FAST-0320A	FAST-0320C		FAST-0320G	FAST-0320B
		RN	FAST-0318A	FAST-0318C
		MF	FAST-0319A	FAST-0319C
	NPY2	CF					FAST-0333B
		HS	FAST-0321A	FAST-0321C			FAST-0321B
		MM					FAST-0332B
		RN	FAST-0324A	FAST-0324C			FAST-0324B
		SS					FAST-0334B
		MF	FAST-0325A	FAST-0325C			FAST-0325B
	NPY4	HS	FAST-0323A	FAST-0323C			FAST-0323B
		RN	FAST-0326A	FAST-0326C
		MF	FAST-0327A	FAST-0327C
	NPY5	HS	FAST-0322A	FAST-0322C			FAST-0322B
		RN	FAST-0328A
		MF	FAST-0329A	FAST-0329C
	GPR7	HS	FAST-0290A	FAST-0290C		FAST-0290G	FAST-0290B
		MM	FAST-0291A
		RN	FAST-0292A
	GPR8	HS	FAST-0310A	FAST-0310C		FAST-0310G	FAST-0310B
	NPFF1	HS		FAST-0412C		FAST-0412G	FAST-0412B
	NPFF2S	HS	FAST-0295A			FAST-0295G	FAST-0295B
	NPS (Ile)	HS	FAST-0301A				FAST-0301B
	NPS (Asn)	HS	FAST-0300A		FAST-0300I		FAST-0300B
	QRFP (GPR103)	HS	FAST-0302A
Neurotensin	NTS1	HS	FAST-0330A	FAST-0330C	FAST-0330I	FAST-0330G	FAST-0330B
	NTS2	HS	FAST-0331A		FAST-0331I		FAST-0331B
NMDA	GRIN1	HS					FAST-0361B
Nociceptin	ORL1	HS		FAST-0360C		FAST-0360G	FAST-0360B
		RN					FAST-0362B
Oleoylethanolamide	GPR119*	HS		FAST-0370C
Opioid	OP1 (d)	HS	FAST-0379A	FAST-0379C		FAST-0379G	FAST-0379B
		RN		FAST-0378C
	OP2 (k)	HS	FAST-0380A	FAST-0380C		FAST-0380G	FAST-0380B
		MM		FAST-0375C
		RN		FAST-0376C
	OP3 (µ)	HS	FAST-0381A	FAST-0381C		FAST-0381G	FAST-0381B	FAST-0381E
		MM		FAST-0382C		FAST-0382G
		RN		FAST-0383C		FAST-0383G	FAST-0383B
Orexin	OX1	HS	FAST-0390A		FAST-0390I		FAST-0390B
		MM	FAST-0394A
		RN	FAST-0392A		FAST-0392I
	OX2	HS	FAST-0391A		FAST-0391I		FAST-0391B
		MM	FAST-0395A
		RN	FAST-0393A		FAST-0393I
Parathyroid	PTH1	HS		FAST-0140C
hormone	PTH2	HS		FAST-0141C
pH sensing	GPR4	HS		FAST-0901C
		MM		FAST-0883C
		RN		FAST-0884C
		CF		FAST-0885C
	GPR65	HS		FAST-0927C	FAST-0927I
		MM		FAST-0929C
		RN		FAST-0880C
	GPR68 (OGR1)	HS		FAST-0928C	FAST-0928I
		MM		FAST-0881C
		RN		FAST-0882C
Platelet-Activating Factor	PAF	HS	FAST-0650A	FAST-0650C
Prokineticin	PKR1	HS	FAST-0400A	FAST-0400C			FAST-0400B
	PKR2	HS	FAST-0401A	FAST-0401C	FAST-0401I		FAST-0401B
Prolactin-releasing peptide	PrRP (GPR10)	HS	FAST-0410A
Prostanoid	DP2/CRTH2	HS	FAST-0420A	FAST-0420C		FAST-0420G	FAST-0420B
	DP	HS	FAST-0430A	FAST-0430C			FAST-0430B
	EP1	HS	FAST-0432A				FAST-0432B
	EP2	HS		FAST-0443C			FAST-0443B	FAST-0443E
	EP3	HS	FAST-0444A				FAST-0444B
	EP4	HS	FAST-0431A	FAST-0431C			FAST-0431B
	FP	HS			FAST-0433I
	IP1	HS		FAST-0434C	FAST-0434I
	TP	HS	FAST-0438A		FAST-0438I
Protease-activated	PAR1	HS	FAST-0439A		FAST-0439I	FAST-0439G
	PAR2	HS	FAST-0440A		FAST-0440I	FAST-0440G
	PAR3	HS	FAST-0441A
	PAR4	HS	FAST-0442A
Purinergic	P2Y1	HS			FAST-0452I
	P2Y2	HS			FAST-0453I
	P2Y4*	HS			FAST-0454I
	P2Y6	HS	FAST-0455A		FAST-0455I
	P2Y6	MM			FAST-0459I
	P2Y11*	HS	FAST-0456A
	P2Y12	HS	FAST-0458A
	P2Y14	HS				FAST-0959G
Relaxin	RXFP1	HS		FAST-0469C
		MM		FAST-0464C
		RN		FAST-0465C
		CF		FAST-0466C
		OC		FAST-0467C
		SS		FAST-0468C
	RXFP3 (GPCR135)	HS	FAST-0470A	FAST-0470C		FAST-0470G
	RXFP4 (GPCR142)	HS	FAST-0471A	FAST-0471C		FAST-0471G
		MM				FAST-0473G
Serotonin	5-HT1A	HS	FAST-0500A	FAST-0500C		FAST-0500G	FAST-0500B
		MM				FAST-0475G	FAST-0475B
		RN				FAST-0515G	FAST-0515B
		CF				FAST-0476G	FAST-0476B
		OC				FAST-0477G	FAST-0477B
	5-HT1B	HS		FAST-0501C		FAST-0501G	FAST-0501B
		MM				FAST-0478G	FAST-0478B
		RN		FAST-0516C		FAST-0516G	FAST-0516B
		CF				FAST-0479G	FAST-0479B
		MF		FAST-0474C		FAST-0474G	FAST-0474B
		OC					FAST-0480B
	5-HT1D	HS	FAST-0502A			FAST-0502G	FAST-0502B
		MM	FAST-0481A				FAST-0481B
		RN	FAST-0482A				FAST-0482B
		CF					FAST-0483B
		OC					FAST-0484B
	5-HT1E	HS		FAST-0503C		FAST-0503G	FAST-0503B
		CF					FAST-0485B
		OC					FAST-0486B
	5-HT1F	HS		FAST-0504C		FAST-0504G	FAST-0504B
		MM					FAST-0487B
		RN					FAST-0488B
		CF				FAST-0489G	FAST-0489B
		OC				FAST-0490G	FAST-0490B
	5-HT2A	HS	FAST-0505A		FAST-0505I		FAST-0505B
		MM			FAST-0491I		FAST-0491B
		RN	FAST-0517A		FAST-0517I		FAST-0517B
		CF			FAST-0492I		FAST-0492B
		OC			FAST-0493I		FAST-0493B
	5-HT2B	HS	FAST-0506A		FAST-0506I		FAST-0506B
		RN	FAST-0518A		FAST-0518I
	5-HT2C non edited	HS	FAST-0508A		FAST-0508I		FAST-0508B
		MM			FAST-0496I
		RN	FAST-0519A		FAST-0519I		FAST-0519B
	5-HT2C edited	HS	FAST-0507A		FAST-0507I		FAST-0507B
	5-HT3	HS	FAST-0512A				FAST-0512B
	5-HT4e	HS		FAST-0513C			FAST-0513B
		RN		FAST-0495C
	5-HT5a	HS	FAST-0510A				FAST-0510B
	5-HT6	HS	FAST-0509A	FAST-0509C			FAST-0509B
		MM		FAST-0590C			FAST-0590B
		RN		FAST-0494C
	5-HT7a	HS		FAST-0511C			FAST-0511B
		MM		FAST-0498C			FAST-0498B
		RN		FAST-0499C			FAST-0499B
Sigma	s1	HS					FAST-0514B
Somatostatin	sst1	HS				FAST-0520G	FAST-0520B
	sst2	HS	FAST-0521A	FAST-0521C		FAST-0521G	FAST-0521B
	sst3	HS	FAST-0522A	FAST-0522C		FAST-0522G	FAST-0522B
	sst4	HS	FAST-0523A	FAST-0523C		FAST-0523G	FAST-0523B
		RN		FAST-0525C
	sst5	HS	FAST-0524A	FAST-0524C		FAST-0524G	FAST-0524B
Sphingosine	S1P1 (Edg1)	HS	FAST-0197A	FAST-0197C		FAST-0197G
		MM	FAST-0625A
		RN	FAST-0202A	FAST-0202C
		FS	FAST-0203A
		CP	FAST-0627A
	S1P2 (Edg5)	HS	FAST-0198A
	S1P3 (Edg3)	HS	FAST-0199A
		CP	FAST-0628A
	S1P4(Edg6)	HS	FAST-0200A						FAST-0200T
	S1P5(Edg8)	HS	FAST-0201A			FAST-0201G		FAST-0201E
		MM	FAST-0626A
		FS	FAST-0204A
		CP	FAST-0629A
Succinate/Keto glutarate	GPR91	HS	FAST-0450A	FAST-0450C
		MM	FAST-0449A	FAST-0449C
		RN	FAST-0451A	FAST-0451C
	GPR99	HS	FAST-0940A
Trace amine	TAAR1 (TA1)	HS		FAST-0987C
		MM		FAST-0894C
		RN		FAST-0895C
		MF		FAST-0893C
	TAAR2 (GPR58)	HS	FAST-0923***
	TAAR5 (PNR)	HS	FAST-0952***
	TAAR6 (TA4)	HS	FAST-0989***
	TAAR8 (TA5)	HS	FAST-0990***
	TAAR9 (TA3)	HS	FAST-0988***
TRH	TRH1	HS	FAST-0530A		FAST-0530I		FAST-0530B
Tyrosine kinase receptor	EGFR	HS	FAST-1600A
Urotensin II	UT-II	HS	FAST-0540A		FAST-0540I		FAST-0540B
		RN	FAST-0541A
Vasopressin	V1a	HS	FAST-0550A		FAST-0550I		FAST-0550B
		MM	FAST-0546A
		RN	FAST-0555A		FAST-0555I
		CF	FAST-0556A		FAST-0556I
		OC	FAST-0547A
	V1b	HS	FAST-0551A		FAST-0551I		FAST-0551B
		RN			FAST-0553I		FAST-0553B
	V2	HS	FAST-0552A	FAST-0552C	FAST-0552I		FAST-0552B
		RN		FAST-0557C
		CF		FAST-0558C
	OT (oxytocin)	HS	FAST-0554A		FAST-0554I
		MM	FAST-0548A
		RN	FAST-0559A		FAST-0559I
		OC	FAST-0549A
VIP/PACAP	PAC1	HS	FAST-0560A	FAST-0560C
	VPAC1	HS	FAST-0561A	FAST-0561C			FAST-0561B	FAST-0561E
	VPAC2	HS	FAST-0562A	FAST-0562C

HS = Homo sapiens ; MM = Mus musculus ; RN = Rattus norvegicus ; CF = Canis familiaris ; CP = Guinea Pig (Cavia porcellus) ; RH = Rhesus monkey (Macaca mulatta) ; OC = Rabbit (Oryctolagus cuniculus) ; MF = Macaca fascicularis ; SS = Pig (Sus scrofa) ; FS = Cat (Felis silvestris catus) ; MA = Syrian hamster (Mesocricetus auratus)
*: Receptors could have limited access due to patent restrictions in certain territories
**: this assay is performed using fluorescent calcium measurement
***: means that the cell line is available for functional assay. It has been validated for mRNA, cell surface expression and constitutive activity but not with a ligand