Reaction BiologyのKinase HotSpot™ Assayでは、Gold StandardのRIによるダイレクトな測定をメインに行っており、再現性が高くfalse の少ないデータを提供します。現在、700種類を超えるキナーゼを対象に試験が可能です。一部、Lipid KinasesとDiacylglycerol KinasesはADP-Glo™を使用しています。
- HotSpot™ Wild type Kinases (398キナーゼ)
- HotSpot™ Mutant Kinases (346キナーゼ)
- Lipid Kinases (23キナーゼ)
- Diacylglycerol Kinases (10キナーゼ)
- HotSpot™ Special Kinases (15キナーゼ)
Kinase HotSpot™ Assay - Wild Type Kinases
| Target name |
|---|
| 1 | ABL1 |
| 2 | ABL2/ARG |
| 3 | ACK1 |
| 4 | AKT1 |
| 5 | AKT2 |
| 6 | AKT3 |
| 7 | ALK |
| 8 | ALK1/ACVRL1 |
| 9 | ALK2/ACVR1 |
| 10 | ALK3/BMPR1A |
| 11 | ALK4/ACVR1B |
| 12 | ALK5/TGFBR1 |
| 13 | ALK6/BMPR1B |
| 14 | ARAF |
| 15 | ARK5/NUAK1 |
| 16 | ASK1/MAP3K5 |
| 17 | Aurora A |
| 18 | Aurora B |
| 19 | Aurora C |
| 20 | AXL |
| 21 | BLK |
| 22 | BMPR2 |
| 23 | BMX/ETK |
| 24 | BRAF |
| 25 | BRK |
| 26 | BRSK1 |
| 27 | BRSK2 |
| 28 | BTK |
| 29 | CAMK1a |
| 30 | CAMK1b |
| 31 | CAMK1d |
| 32 | CAMK1g |
| 33 | CAMK2a |
| 34 | CAMK2b |
| 35 | CAMK2d |
| 36 | CAMK2g |
| 37 | CAMK4 |
| 38 | CAMKK1 |
| 39 | CAMKK2 |
| 40 | CDC7/DBF4 |
| 41 | CDK1/cyclin A |
| 42 | CDK1/cyclin B |
| 43 | CDK1/cyclin E |
| 44 | CDK2/cyclin A1 |
| 45 | CDK2/cyclin A |
| 46 | CDK2/cyclin E |
| 47 | CDK2/cyclin E2 |
| 48 | CDK2/cyclin O |
| 49 | CDK3/cyclin C |
| 50 | CDK3/cyclin E |
| 51 | CDK3/cyclin E2 |
| 52 | CDK4/cyclin D1 |
| 53 | CDK4/cyclin D2 |
| 54 | CDK4/cyclin D3 |
| 55 | CDK5/p25 |
| 56 | CDK5/p35 |
| 57 | CDK6/cyclin D1 |
| 58 | CDK6/cyclin D2 |
| 59 | CDK6/cyclin D3 |
| 60 | CDK7/cyclin H |
| 61 | CDK9/cyclin K |
| 62 | CDK9/cyclin T1 |
| 63 | CDK9/cyclin T2 |
| 64 | CDK14 (PFTK1)/cyclin Y |
| 65 | CDK15/cyclin A2 |
| 66 | CDK15/cyclin B1 |
| 67 | CDK16/cyclin Y |
| 68 | CDK17/cyclin Y (PCTK2) |
| 69 | CDK18/cyclin Y |
| 70 | CHK1 |
| 71 | CHK2 |
| 72 | CK1a1 |
| 73 | CK1a1L |
| 74 | CK1d |
| 75 | CK1epsilon |
| 76 | CK1g1 |
| 77 | CK1g2 |
| 78 | CK1g3 |
| 79 | CK2a |
| 80 | CK2a2 |
| 81 | c-Kit |
| 82 | CLK1 |
| 83 | CLK2 |
| 84 | CLK3 |
| 85 | CLK4 |
| 86 | c-MER |
| 87 | c-MET |
| 88 | COT1/MAP3K8 |
| 89 | CSK |
| 90 | c-Src |
| 91 | CTK/MATK |
| 92 | DAPK1 |
| 93 | DAPK2 |
| 94 | DCAMKL1 |
| 95 | DCAMKL2 |
| 96 | DCAMKL3 |
| 97 | DDR1 |
| 98 | DDR2 |
| 99 | DMPK |
| 100 | DMPK2/CDC42BPG |
| 101 | DRAK1/STK17A |
| 102 | DYRK1/DYRK1A |
| 103 | DYRK1B |
| 104 | DYRK2 |
| 105 | DYRK3 |
| 106 | DYRK4 |
| 107 | EGFR |
| 108 | EPHA1 |
| 109 | EPHA2 |
| 110 | EPHA3 |
| 111 | EPHA4 |
| 112 | EPHA5 |
| 113 | EPHA6 |
| 114 | EPHA7 |
| 115 | EPHA8 |
| 116 | EPHB1 |
| 117 | EPHB2 |
| 118 | EPHB3 |
| 119 | EPHB4 |
| 120 | ERBB2/HER2 |
| 121 | ERBB4/HER4 |
| 122 | ERK1/MAPK3 |
| 123 | ERK2/MAPK1 |
| 124 | ERK5/MAPK7 |
| 125 | ERK7/MAPK15 |
| 126 | ERN1/IRE1 |
| 127 | ERN2/IRE2 |
| 128 | FAK/PTK2 |
| 129 | FER |
| 130 | FES/FPS |
| 131 | FGFR1 |
| 132 | FGFR2 |
| 133 | FGFR3 |
| 134 | FGFR4 |
| 135 | FGR |
| 136 | FLT1/VEGFR1 |
| 137 | FLT3 |
| 138 | FLT4/VEGFR3 |
| 139 | FMS |
| 140 | FRK/PTK5 |
| 141 | FYN |
| 142 | GCK/MAP4K2 |
| 143 | GLK/MAP4K3 |
| 144 | GRK1 |
| 145 | GRK2 |
| 146 | GRK3 |
| 147 | GRK4 |
| 148 | GRK5 |
| 149 | GRK6 |
| 150 | GRK7 |
| 151 | GSK3a |
| 152 | GSK3b |
| 153 | Haspin |
| 154 | HCK |
| 155 | HGK/MAP4K4 |
| 156 | HIPK1 |
| 157 | HIPK2 |
| 158 | HIPK3 |
| 159 | HIPK4 |
| 160 | HPK1/MAP4K1 |
| 161 | IGF1R |
| 162 | IKKa/CHUK |
| 163 | IKKb/IKBKB |
| 164 | IKKe/IKBKE |
| 165 | IR |
| 166 | IRAK1 |
| 167 | IRAK4 |
| 168 | IRR/INSRR |
| 169 | ITK |
| 170 | JAK1 |
| 171 | JAK2 |
| 172 | JAK3 |
| 173 | JNK1 |
| 174 | JNK2 |
| 175 | JNK3 |
| 176 | KDR/VEGFR2 |
| 177 | KHS/MAP4K5 |
| 178 | LATS1 |
| 179 | LATS2 |
| 180 | LCK |
| 181 | LCK2/ICK |
| 182 | LIMK1 |
| 183 | LIMK2 |
| 184 | LKB1 |
| 185 | LOK/STK10 |
| 186 | LRRK2 |
| 187 | LYN |
| 188 | LYN B |
| 189 | MAK |
| 190 | MAPKAPK2 |
| 191 | MAPKAPK3 |
| 192 | MAPKAPK5/PRAK |
| 193 | MARK1 |
| 194 | MARK2/PAR-1Ba |
| 195 | MARK3 |
| 196 | MARK4 |
| 197 | MAST3 |
| 198 | MASTL |
| 199 | MEK1 |
| 200 | MEK2 |
| 201 | MEK3 |
| 202 | MEK5 |
| 203 | MEKK1 |
| 204 | MEKK2 |
| 205 | MEKK3 |
| 206 | MEKK6 |
| 207 | MELK |
| 208 | MINK/MINK1 |
| 209 | MKK4 |
| 210 | MKK6 |
| 211 | MKK7 |
| 212 | MLCK/MYLK |
| 213 | MLCK2/MYLK2 |
| 214 | MLK1/MAP3K9 |
| 215 | MLK2/MAP3K10 |
| 216 | MLK3/MAP3K11 |
| 217 | MLK4 |
| 218 | MNK1 |
| 219 | MNK2 |
| 220 | MRCKa/CDC42BPA |
| 221 | MRCKb/CDC42BPB |
| 222 | MSK1/RPS6KA5 |
| 223 | MSK2/RPS6KA4 |
| 224 | MSSK1/STK23 |
| 225 | MST1/STK4 |
| 226 | MST2/STK3 |
| 227 | MST3/STK24 |
| 228 | MST4 |
| 229 | MUSK |
| 230 | MYLK3 |
| 231 | MYLK4 |
| 232 | MYO3A |
| 233 | MYO3B |
| 234 | NEK1 |
| 235 | NEK2 |
| 236 | NEK3 |
| 237 | NEK4 |
| 238 | NEK5 |
| 239 | NEK6 |
| 240 | NEK7 |
| 241 | NEK9 |
| 242 | NEK11 |
| 243 | NIM1 |
| 244 | NLK |
| 245 | OSR1/OXSR1 |
| 246 | P38a/MAPK14 |
| 247 | P38b/MAPK11 |
| 248 | P38d/MAPK13 |
| 249 | P38g/MAPK12 |
| 250 | p70S6K/RPS6KB1 |
| 251 | p70S6Kb/RPS6KB2 |
| 252 | PAK1 |
| 253 | PAK2 |
| 254 | PAK3 |
| 255 | PAK4 |
| 256 | PAK5 |
| 257 | PAK6 |
| 258 | PASK |
| 259 | PBK/TOPK |
| 260 | PDGFRa |
| 261 | PDGFRb |
| 262 | PDK1/PDPK1 |
| 263 | PHKg1 |
| 264 | PHKg2 |
| 265 | PIM1 |
| 266 | PIM2 |
| 267 | PIM3 |
| 268 | PKA |
| 269 | PKAcb |
| 270 | PKAcg |
| 271 | PKCa |
| 272 | PKCb1 |
| 273 | PKCb2 |
| 274 | PKCd |
| 275 | PKCepsilon |
| 276 | PKCeta |
| 277 | PKCg |
| 278 | PKCiota |
| 279 | PKCmu/PRKD1 |
| 280 | PKCnu/PRKD3 |
| 281 | PKCtheta |
| 282 | PKCzeta |
| 283 | PKD2/PRKD2 |
| 284 | PKG1a |
| 285 | PKG1b |
| 286 | PKG2/PRKG2 |
| 287 | PKN1/PRK1 |
| 288 | PKN2/PRK2 |
| 289 | PKN3/PRK3 |
| 290 | PLK1 |
| 291 | PLK2 |
| 292 | PLK3 |
| 293 | PLK4/SAK |
| 294 | PRKX |
| 295 | PYK2 |
| 296 | RAF1 |
| 297 | RET |
| 298 | RIPK2 |
| 299 | RIPK4 |
| 300 | RIPK5 |
| 301 | ROCK1 |
| 302 | ROCK2 |
| 303 | RON/MST1R |
| 304 | ROS/ROS1 |
| 305 | RSK1 |
| 306 | RSK2 |
| 307 | RSK3 |
| 308 | RSK4 |
| 309 | SBK1 |
| 310 | SGK1 |
| 311 | SGK2 |
| 312 | SGK3/SGKL |
| 313 | SIK1 |
| 314 | SIK2 |
| 315 | SIK3 |
| 316 | SLK/STK2 |
| 317 | SNARK/NUAK2 |
| 318 | SNRK |
| 319 | SRMS |
| 320 | SRPK1 |
| 321 | SRPK2 |
| 322 | SSTK/TSSK6 |
| 323 | STK16 |
| 324 | STK21/CIT |
| 325 | STK22D/TSSK1 |
| 326 | STK25/YSK1 |
| 327 | STK32A/YANK1 |
| 328 | STK32B/YANK2 |
| 329 | STK32C/YANK3 |
| 330 | STK33 |
| 331 | STK35/CLIK1 |
| 332 | STK38/NDR1 |
| 333 | STK38L/NDR2 |
| 334 | STK39/STLK3 |
| 335 | SYK |
| 336 | TAK1 |
| 337 | TAOK1 |
| 338 | TAOK2 |
| 339 | TAOK3/JIK |
| 340 | TBK1 |
| 341 | TEC |
| 342 | TESK1 |
| 343 | TESK2 |
| 344 | TGFBR2 |
| 345 | TIE2/TEK |
| 346 | TLK1 |
| 347 | TLK2 |
| 348 | TNIK |
| 349 | TNK1 |
| 350 | TRKA |
| 351 | TRKB |
| 352 | TRKC |
| 353 | TSSK2 |
| 354 | TSSK3/STK22C |
| 355 | TSSK4 |
| 356 | TTBK1 |
| 357 | TTBK2 |
| 358 | TXK |
| 359 | TYK1/LTK |
| 360 | TYK2 |
| 361 | TYRO3/SKY |
| 362 | ULK1 |
| 363 | ULK2 |
| 364 | ULK3 |
| 365 | VRK1 |
| 366 | VRK2 |
| 367 | WNK1 |
| 368 | WNK2 |
| 369 | WNK3 |
| 370 | YES/YES1 |
| 371 | YSK4/MAP3K19 |
| 372 | ZAK/MLTK |
| 373 | ZAP70 |
| 374 | ZIPK/DAPK3 |
| 375 | AMPK(A1/B1/G1) |
| 376 | AMPK(A1/B1/G2) |
| 377 | AMPK(A1/B1/G3) |
| 378 | AMPK(A1/B2/G1) |
| 379 | AMPK (A1/B2/G2) |
| 380 | AMPK (A1/B2/G3) |
| 381 | AMPK(A2/B1/G1) |
| 382 | AMPK (A2/B1/G2) |
| 383 | AMPK (A2/B1/G3) |
| 384 | AMPK(A2/B2/G1) |
| 385 | AMPK(A2/B2/G2) |
| 386 | AMPK(A2/B2/G3) |
| 387 | DNA-PK |
| 388 | EEF2K |
| 389 | EIF2AK1/HRI |
| 390 | EIF2AK2 |
| 391 | EIF2AK3/PERK |
| 392 | EIF2AK4/GCN2 |
| 393 | mTOR/FRAP1 |
| 394 | PDK1/PDHK1 |
| 395 | PDK2/PDHK2 |
| 396 | PDK3/PDHK3 |
| 397 | PDK4/PDHK4 |
| 398 | TRPM7/CHAK1 |
Kinase HotSpot™ Assay - Mutant Kinases
| Target name |
|---|
| 1 | ABL1 (E255K) |
| 2 | ABL1 (E255V) |
| 3 | ABL1 (F317I) |
| 4 | ABL1 (F317L) |
| 5 | ABL1 (G250E) |
| 6 | ABL1 (H396P) |
| 7 | ABL1 (M351T) |
| 8 | ABL1 (Q252H) |
| 9 | ABL1 (T315I) |
| 10 | ABL1 (V299L) |
| 11 | ABL1 (Y245F) |
| 12 | ABL1 (Y245F/Y412F) |
| 13 | ABL1 (Y253F) |
| 14 | ABL1 (Y253H) |
| 15 | AKT1 (E17K) |
| 16 | AKT2 (E17K) |
| 17 | AKT3 (E17K) |
| 18 | AKT3 (G171R) |
| 19 | ALK (C1156Y) |
| 20 | ALK (F1174L) |
| 21 | ALK (F1174L)-EML4 |
| 22 | ALK (F1174L)-NPM1 |
| 23 | ALK (F1174S) |
| 24 | ALK (G1202R) |
| 25 | ALK (G1269A) |
| 26 | ALK (G1269S) |
| 27 | ALK (I1171N/D1203N) |
| 28 | ALK (L1152R) |
| 29 | ALK (L1196M) |
| 30 | ALK (L1196M/G1202R) |
| 31 | ALK (R1275Q) |
| 32 | ALK (S1206R) |
| 33 | ALK (T1151M) |
| 34 | ALK (T1151-L1152insT) |
| 35 | ALK-EML4 (Eex6Aex20) |
| 36 | ALK-EML4 (Eex13Aex20) |
| 37 | ALK-EML4 (Eex14Aex20) |
| 38 | ALK-EML4 (Eex20Aex20) |
| 39 | ALK-KIF5B (Kex24Aex20) |
| 40 | ALK-KLC1 (Kex8Aex20) |
| 41 | ALK-NPM1 |
| 42 | ALK-STRN (Sex3Aex20) |
| 43 | ALK-TFG |
| 44 | ALK-TFG (Tex4Aex20) |
| 45 | ALK-TPM1 |
| 46 | ALK-TPM3 |
| 47 | ALK2 (Q207D) |
| 48 | ALK2 (R206H) |
| 49 | Aurora B (G160L) |
| 50 | AXL (R499C) |
| 51 | BRAF (d485-489/P490Y) |
| 52 | BRAF (G464V) |
| 53 | BRAF (G469A) |
| 54 | BRAF (K601E) |
| 55 | BRAF (L597V) |
| 56 | BRAF (T599_V600insT) |
| 57 | BRAF (V599E) |
| 58 | BRAF (V600A) |
| 59 | BRAF (V600D) |
| 60 | BRAF (V600K) |
| 61 | BRAF (R506_K507insVLR) |
| 62 | BRAF-FAM131B (Fex2Bex9) |
| 63 | BRAF-KIAA1549 (Kex15Bex9) |
| 64 | BRAF-KIAA1549 (Kex16Bex9) |
| 65 | BRAF-SRGAP3 (Sex12Bex9) |
| 66 | BTK (C481S) |
| 67 | BTK (E41K) |
| 68 | BTK (P190K) |
| 69 | BTK (T474I) |
| 70 | BTK (Y485F) |
| 71 | CHK2 (I157T) |
| 72 | CK1a1 (E42C) |
| 73 | CK1a1 (I35C) |
| 74 | CK1epsilon (R178C) |
| 75 | c-Kit (d557-558) |
| 76 | c-Kit (A829P) |
| 77 | c-Kit (d557-558/Y823D) |
| 78 | c-Kit (D816E) |
| 79 | c-Kit (D816F) |
| 80 | c-Kit (D816H) |
| 81 | c-Kit (D816I) |
| 82 | c-Kit (D816V) |
| 83 | c-Kit (D816Y) |
| 84 | c-Kit (D820E) |
| 85 | c-Kit (D820Y) |
| 86 | c-Kit (N822K) |
| 87 | c-Kit (T670I) |
| 88 | c-Kit (V559A) |
| 89 | c-Kit (V559D) |
| 90 | c-Kit (V559D/V654A) |
| 91 | c-Kit (V559D/T670I) |
| 92 | c-Kit (V560G) |
| 93 | c-Kit (V560G/D816V) |
| 94 | c-Kit (V560G/N822K) |
| 95 | c-Kit (V654A) |
| 96 | c-Kit (Y823D) |
| 97 | c-MER (A708S) |
| 98 | c-MET (D1213H) |
| 99 | c-MET (D1228A) |
| 100 | c-MET (D1228G) |
| 101 | c-MET (D1228H) |
| 102 | c-MET (D1228N) |
| 103 | c-MET (D1228V) |
| 104 | c-MET (D1228Y) |
| 105 | c-MET (Del Ex14) |
| 106 | c-MET (R970C) |
| 107 | c-MET (F1200I) |
| 108 | c-MET (G1163R) |
| 109 | c-MET (H1094L) |
| 110 | c-MET (H1094Y) |
| 111 | c-MET (K1244R) |
| 112 | c-MET (L1195F) |
| 113 | c-MET (L1195V) |
| 114 | c-MET (M1250I) |
| 115 | c-MET (M1250T) |
| 116 | c-MET (P991S) |
| 117 | c-MET (R1227K) |
| 118 | c-MET (T992I) |
| 119 | c-MET (T1173I) |
| 120 | c-MET (V1092I) |
| 121 | c-MET (Y1230A) |
| 122 | c-MET (Y1230C) |
| 123 | c-MET (Y1230D) |
| 124 | c-MET (Y1230H) |
| 125 | c-MET (Y1230S) |
| 126 | c-MET (Y1235D) |
| 127 | c-MET-KIF5B (Kex24Mex14) |
| 128 | c-MET-TFG (Tex5Mex15) |
| 129 | c-Src (T341M) |
| 130 | c-SRC (Y530F) |
| 131 | DDR2 (N456S) |
| 132 | DDR2 (T654M) |
| 133 | EGFR (A763_Y764insFHEA) |
| 134 | EGFR (A763_Y764insFQEA) |
| 135 | EGFR (A767_S768insTLA) |
| 136 | EGFR (C775S/T790M/L858R) |
| 137 | EGFR (C797A) |
| 138 | EGFR (C797G/L858R) |
| 139 | EGFR (C797S) |
| 140 | EGFR (C797S/L858R) |
| 141 | EGFR (d746) |
| 142 | EGFR (d746-750) |
| 143 | EGFR (d746-750/C775S/T790M/L858R) |
| 144 | EGFR (d746-750/C797A) |
| 145 | EGFR (d746-750/C797S) |
| 146 | EGFR (d746-750/G724S) |
| 147 | EGFR (d746-750/S768I) |
| 148 | EGFR (d746-750/T790M) |
| 149 | EGFR (d746-750/T790M/C797S) |
| 150 | EGFR (d746-750/T790M/C797S/L858R) |
| 151 | EGFR (d746-750/T790M/L792F) |
| 152 | EGFR (d746-750/T790M/L792H) |
| 153 | EGFR (d746-750/T790M/L798I) |
| 154 | EGFR (d746-750/T790M/L858R) |
| 155 | EGFR (d747-749) |
| 156 | EGFR (d747-749/A750P) |
| 157 | EGFR (d747-752/P753S) |
| 158 | EGFR (d752-759) |
| 159 | EGFR (D761Y) |
| 160 | EGFR (D770GY) |
| 161 | EGFR (D770_N771insG) |
| 162 | EGFR (D770_N771insNPG) |
| 163 | EGFR (D770_N771insNPG/T790M) |
| 164 | EGFR (G719C) |
| 165 | EGFR (G719D) |
| 166 | EGFR (G719S) |
| 167 | EGFR (K716A) |
| 168 | EGFR (K716A/C797S/L858R) |
| 169 | EGFR (K716A/T790M/C797S/L858R) |
| 170 | EGFR (K716Q/L718Q) |
| 171 | EGFR (K728A) |
| 172 | EGFR (K728A/T790M/C797S/L858R) |
| 173 | EGFR (L718Q) |
| 174 | EGFR (L747S) |
| 175 | EGFR (L792F) |
| 176 | EGFR (L792F/L858R) |
| 177 | EGFR (L792H) |
| 178 | EGFR (L792H/C797S/L858R) |
| 179 | EGFR (L792H/L858R) |
| 180 | EGFR (L858R) |
| 181 | EGFR (L861Q) |
| 182 | EGFR (N771_P772insH) |
| 183 | EGFR (N771_P772insN) |
| 184 | EGFR (R999A) |
| 185 | EGFR (S768I) |
| 186 | EGFR (T790M) |
| 187 | EGFR (T790M/C797G/L858R) |
| 188 | EGFR (T790M/C797S) |
| 189 | EGFR (T790M/C797S/L858R) |
| 190 | EGFR (T790M/L858R) |
| 191 | EGFR (T790M/L792F/L858R) |
| 192 | EGFR (T790M/L792H/L858R) |
| 193 | EGFR (T790M/L792F/C797S/L858R) |
| 194 | EGFR (T790M/L792H/C797S/L858R) |
| 195 | EGFR (V769_D770insGE) |
| 196 | EGFR (V948R) |
| 197 | ERBB2 (A775_G776insYVMA) |
| 198 | ERBB2 (D769H) |
| 199 | ERBB2 (D769Y) |
| 200 | ERBB2 (P780_Y781insGSP) |
| 201 | ERBB2 (P1170A) |
| 202 | ERBB2 (R896C) |
| 203 | ERBB2 (V777L) |
| 204 | ERBB2 (V777_G778insCG) |
| 205 | ERBB2 (V956R) |
| 206 | ERN1/IRE1 (R727A) |
| 207 | ERN1/IRE1 (R728A) |
| 208 | ERN1/IRE1 (R727A/R728A) |
| 209 | FGFR1 (V561M) |
| 210 | FGFR1 (W666R) |
| 211 | FGFR1OP-FGFR1 |
| 212 | FGFR2 (C491A) |
| 213 | FGFR2 (C491F) |
| 214 | FGFR2 (C491S) |
| 215 | FGFR2 (C491A/V564I) |
| 216 | FGFR2 (C491A/V564L) |
| 217 | FGFR2 (C491S/V564L) |
| 218 | FGFR2 (E565A) |
| 219 | FGFR2 (E565G) |
| 220 | FGFR2 (K526E) |
| 221 | FGFR2 (K641R) |
| 222 | FGFR2 (K659N) |
| 223 | FGFR2 (M420I) |
| 224 | FGFR2 (N549H) |
| 225 | FGFR2 (N549K) |
| 226 | FGFR2 (R612T) |
| 227 | FGFR2 (V564F) |
| 228 | FGFR2 (V564I) |
| 229 | FGFR2 (V564L) |
| 230 | FGFR3 (V555M) |
| 231 | FGFR3 (G697C) |
| 232 | FGFR3 (K650E) |
| 233 | FGFR3 (K650M) |
| 234 | FGFR3 (K650Q) |
| 235 | FGFR4 (N535K) |
| 236 | FGFR4 (V550E) |
| 237 | FGFR4 (V550L) |
| 238 | FGFR4 (V550M) |
| 239 | FLT3 (D835Y) |
| 240 | FLT3 (ITD) |
| 241 | FLT3 (ITD)-NPOS |
| 242 | FLT3 (ITD)-W51 |
| 243 | FLT3 (F594_R595insR) |
| 244 | FLT3 (F594_R595insREY) |
| 245 | FLT3 (F691L/D835Y) |
| 246 | FLT3 (R595_E596insEY) |
| 247 | FLT3 (Y591_V592insVDFREYEYD) |
| 248 | FLT3 (Y591-V592insVDFREYEYD/D835Y) |
| 249 | FLT3 (Y591-V592insVDFREYEYD/F691L) |
| 250 | FYN (Y531F) |
| 251 | GSK3b (C199A) |
| 252 | JAK2 (V617F) |
| 253 | LRRK2 (G2019S) |
| 254 | LRRK2 (I2020T) |
| 255 | LRRK2 (R1441C) |
| 256 | MEK1 (P124L) |
| 257 | MELK (T460M) |
| 258 | p38a (T106M) |
| 259 | PAK2 (Y443N) |
| 260 | PDGFRa (D842V) |
| 261 | PDGFRa (G680R) |
| 262 | PDGFRa (T674I) |
| 263 | PDGFRa-FIP1L1 |
| 264 | PDGFRa (V561D) |
| 265 | PDGFRb-TPM3 |
| 266 | PKA (L206R) |
| 267 | PKA-DNAJB1 |
| 268 | PKD2 (G870E) |
| 269 | PKD2/PRKD2 (G848E) |
| 270 | PKMzeta |
| 271 | PKN1-ANXA4 (Aex2Pex13) |
| 272 | PKN1-TECR (Tex1Pex10) |
| 273 | RAF1 (R391W) |
| 274 | RET (A883F) |
| 275 | RET (E732K) |
| 276 | RET (E762Q) |
| 277 | RET (G691S) |
| 278 | RET (G810C) |
| 279 | RET (G810R) |
| 280 | RET (G810S) |
| 281 | RET (G810S/M918T) |
| 282 | RET (L730I) |
| 283 | RET (L730M) |
| 284 | RET (L790F) |
| 285 | RET (M918T) |
| 286 | RET (R749T) |
| 287 | RET (R813Q) |
| 288 | RET (R912P) |
| 289 | RET (S891A) |
| 290 | RET (S904F) |
| 291 | RET (S904A) |
| 292 | RET (V738A) |
| 293 | RET (V778I) |
| 294 | RET (V804E) |
| 295 | RET (V804L) |
| 296 | RET (V804M) |
| 297 | RET (V804M/G810S) |
| 298 | RET (Y791F) |
| 299 | RET (Y806C) |
| 300 | RET (Y806H) |
| 301 | RET (Y806N) |
| 302 | RET-BCR |
| 303 | RET-CCDC6 (PTC1) |
| 304 | RET-KIF5B (Kex15Rex14) |
| 305 | RET (V804L)-KIF5B |
| 306 | RET (V804M)-KIF5B |
| 307 | RET-PRKAR1A (PTC2) |
| 308 | RET-NCOA4 (PTC3) |
| 309 | ROS1 (G2032R) |
| 310 | ROS1 (G2101A) |
| 311 | ROS1 (G2101C) |
| 312 | ROS1-GOPC |
| 313 | ROS1 (L2086F) |
| 314 | ROS1-TPM3 |
| 315 | RSK2 (I416V) |
| 316 | RSK2 (L608F) |
| 317 | TIE2 (A1124V) |
| 318 | TIE2 (P883A) |
| 319 | TIE2 (R849W) |
| 320 | TIE2 (R915C) |
| 321 | TIE2 (Y897C) |
| 322 | TIE2 (Y897H) |
| 323 | TIE2 (Y897H/R915C) |
| 324 | TIE2 (Y897S) |
| 325 | TIE2 (Y1108F) |
| 326 | TRKA (A608D) |
| 327 | TRKA (F589L) |
| 328 | TRKA (G595R) |
| 329 | TRKA (G595R/A608D) |
| 330 | TRKA (G595R/L657M) |
| 331 | TRKA (G595R/G667A) |
| 332 | TRKA (G595R/G667C) |
| 333 | TRKA (G595R/G667S) |
| 334 | TRKA (G667C) |
| 335 | TRKA (G667S) |
| 336 | TRKA (L657M) |
| 337 | TRKA-TFG (TRK-T3) |
| 338 | TRKA-TPM3 |
| 339 | TRKA-TPR |
| 340 | TRKC (G623E) |
| 341 | TRKC (G623R) |
| 342 | TRKC (G623R/L686M) |
| 343 | TRKC (G696A) |
| 344 | TRKC (L686M) |
| 345 | YES1 (T348I) |
| 346 | ZAP70 (Y319F) |
Kinase Assay - Lipid Kinases
| Target name |
|---|
| 1 | PI3K (p110a(E542K)/p85a) |
| 2 | PI3K (p110a(E545K)/p85a) |
| 3 | PI3K (p110a(H1047R)/p85a) |
| 4 | PI3K (p110a/p65a) |
| 5 | PI3Ka (p110a/p85a) |
| 6 | PI3Kb (p110b/p85a) |
| 7 | PI3Kd (p110d/p85a) |
| 8 | PI3Kg (p120g) |
| 9 | PI3KC2a/PIK3C2A |
| 10 | PI3KC2b/PIK3C2B |
| 11 | PI3KC3 |
| 12 | PI4K2A |
| 13 | PI4Ka |
| 14 | PI4Kb |
| 15 | PIP5K1A |
| 16 | PIP5K1B |
| 17 | PIP5K1C |
| 18 | SPHK1 |
| 19 | SPHK2 |
| 20 | PIP4K2A/PIP5K2A |
| 21 | PIP4K2B/PIP5K2B |
| 22 | PIP4K2C/PIP5K2C |
| 23 | PIP5K3/PYKFYVE |
Kinase Assay - Diacylglycerol Kinases
| Target name |
|---|
| 1 | DGKA |
| 2 | DGKB |
| 3 | DGKD |
| 4 | DGKE |
| 5 | DGKG |
| 6 | DGKH |
| 7 | DGKI |
| 8 | DGKK |
| 9 | DGKQ |
| 10 | DGKZ |
Kinase HotSpot™ Assay - Special Kinases
| Target name |
|---|
| 1 | CDK8/cyclin C |
| 2 | CDK12/cyclin K |
| 3 | CDK12 (R722C)/cyclin K |
| 4 | CDK13/cyclin K |
| 5 | CDK19/cyclin C |
| 6 | ERK5/MAPK7 (CD) |
| 7 | GAK |
| 8 | IRAK2 |
| 9 | JAK2 JH1&2 |
| 10 | NEK8 |
| 11 | RIPK3 |
| 12 | TTK |
| 13 | TYK2 JH1&2 |
| 14 | WEE1 |
| 15 | WEE2 |
